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Authié, E.Muteti, D.K.Williams, D.J.L.[Antibody responses to invariant antigens of Trypanosoma congolense in cattle of differing susceptibility to trypanosomiasis]Antibody responses to invariant antigens of Trypanosoma congolense in cattle of differing susceptibility to trypanosomiasis

In order to test the hypothesis that trypanosome cysteine proteinases (CPs) contribute to pathology of trypanosomosis. cattle were immunised with CPl and/or CP2, the major Cps of Trypanosoma congolense, and subsequently challenged with T. congolense. Immunisation had no effect on the establishmen...


Authié, E.Boulange, A.F.Muteti, D.Lalmanach, G.Gauthier, F.Musoke, A.J.[Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite]Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targetting the disease rather than the parasite
Authié, E.Duvallet, G.Robertson, C.Williams, D.J.L.[Antibody response to a 33 kDa cysteine protease of Trypanosoma congolense: Relationship to 'trypanotolerance' in cattle]Antibody response to a 33 kDa cysteine protease of Trypanosoma congolense: Relationship to 'trypanotolerance' in cattle

Trypanosomosis is one of the major constraints on animal production in areas of Africa which have the greatest potential for significant increases in domestic livestock populations and livestock productivity. While the eradication of trypanosomosis from the entire continent is an unrealistic goal...


D'Ieteren, G.D.M.Authié, E.Wissocq, N.M.Murray, M.[Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomiasis]Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomiasis

Approximately 320 East African Zebu cows over 36 months of age were monitored monthly from 1986 to 1992 in nine village herds in an area of high trypanosomiasis risk in southwest Ethiopia where there was resistance to all available trypanocidal drugs. Cows were individually treated with diminazen...


Rowlands, G.J.Mulatu, W.Authié, E.D'Ieteren, G.D.M.Leak, S.G.A.Nagda, S.M.[Effects of trypanosomiasis on reproduction of East African Zebu cows exposed to drug-resistant trypanosomes]Effects of trypanosomiasis on reproduction of East African Zebu cows exposed to drug-resistant trypanosomes

Trypanosomiasis is a serious constraint to livestock production in sub-Saharan Africa. Some breeds of cattle are genetically more resistant to the pathogenic effects of trypanosome infection. We measured B-cell activation and the quantity and isotype of antibody produced at the cellular level in ...


Taylor, K.A.Lutje, V.Kennedy, D.Authié, E.Boulange, A.F.Logan-Henfrey, L.L.Gichuki, B.Gettinby, G.[Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle]Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle

A comparison of T-cell-mediated immune responses in trypanotolerant N'Dama and susceptible Boran cattle during primary infection with tsetse-transmitted Trypanosoma congolense was conducted to assess whether different patterns of T-cell activation occurred during trypanosome infection. Proliferat...


Lutje, V.Taylor, K.A.Kennedy, D.Authié, E.Boulange, A.F.Gettinby, G.[Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection]Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection

T-cell-mediated immune responses to defined antigens of Trypanosoma congolense were measured in cattle undergoing primary infection. The antigens used were the variable surface glycoprotein and two invariant antigens, a 33-kDa cysteine protease (congopain) and a recombinant form of a 69-kDa heat-...


Lutje, V.Mertens, B.Boulange, A.F.Williams, D.J.L.Authié, E.[Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle]Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle

Describes the epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia, the tsetse populations and their relationships to the prevalence of trypanosome infections in cattle. The tsetse challenge to cattle at two sites in the area was estimated as the product of tsetse relati...


Leak, S.G.A.Mulatu, W.Authié, E.D'Ieteren, G.D.M.Peregrine, A.S.Rowlands, G.J.Trail, J.C.M.[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 1. Tsetse challenge and its relationship to trypanosome prevalence in cattle]Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 1. Tsetse challenge and its relationship to trypanosome prevalence in cattle

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