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Cattle from 50 farms in Mukono County, Uganda, were monitored for trypanosomes every second month over an 18-month period (1995–1996) by mini-anion exchange chromatography and haematocrit centrifugation techniques. Eighteen trypanosome isolates collected from cattle during this period were charac...


Olila, D.McDermott, John J.Eisler, M.C.Mitema, E.S.Patzelt, R.J.Clausen, P.H.Poetzsch, C.J.Zessin, K.H.Mehlitz, D.Peregrine, A.S.[Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda]Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda
Barry, A.M.Vial, Leigh K.Diallo, A.Diallo, B.Diall, O.Manstermann, S.Randolph, Thomas F.Clausen, P.H.[Situation de la trypanosomose et de la résistance aux trypanocides dans les élevages de bovins Ndama de la zone cotonnière de Haute Guinée (Guinée-Conakry)]Situation de la trypanosomose et de la résistance aux trypanocides dans les élevages de bovins Ndama de la zone cotonnière de Haute Guinée (Guinée-Conakry)
Grace, DeliaRandolph, Thomas F.Diall, O.Clausen, P.H.[Knowledge, attitude and practices regarding the control of trypanosomosis in three countries in West Africa]Knowledge, attitude and practices regarding the control of trypanosomosis in three countries in West Africa

We carried out a stratified, cluster-randomised, controlled trial in south Mali in 2004 to evaluate the impact of providing information on the diagnosis and treatment of bovine trypanosomosis by farmers. We recruited cattle farmers (444) in 46 villages and used stratified, restricted-randomisatio...


Grace, DeliaRandolph, Thomas F.Diall, O.Clausen, P.H.[Training farmers in rational drug-use improves their management of cattle trypanosomosis: a cluster-randomised trial in south Mali]Training farmers in rational drug-use improves their management of cattle trypanosomosis: a cluster-randomised trial in south Mali

Trypanocidal treatments remain the most widespread method used for the control of African animal trypanosomosis (AAT). However increasing resistance affects the sustainability of this strategy. In general, resistance can be directly attributed to biological factors but it is recognized that insti...


Ouédraogo, D.Kamuanga, M.Savadogo, K.McDermott, John J.Randolph, Thomas F.Diarra, B.Woitag, T.Clausen, P.H.[Facteurs institutionnels et developpement de la resistance aux trypanocides dans la zone cotonniere en Afrique de l'Ouest: Evidence empirique dans la province du kenedougou au Burkina faso]Facteurs institutionnels et developpement de la resistance aux trypanocides dans la zone cotonniere en Afrique de l'Ouest: Evidence empirique dans la province du kenedougou au Burkina faso

This study assessed the degree of isometamidium resistance of trypanosomes infecting cattle in the upper Didessa valley of western Ethiopia. An initial prevalence study was conducted to identify sites with a high risk of trypanosmosis in cattle. The trypanosome prevalence varied widely, with t...


Tewelde, N.Abebe, G.Eisler, M.C.McDermott, John J.Greiner, M.Afework, Y.Kyule, M.Munstermann, S.Zessin, K.H.Clausen, P.H.[Application of field methods to assess isometamidium resistance of trypanosomes in cattle in western Ethiopia]Application of field methods to assess isometamidium resistance of trypanosomes in cattle in western Ethiopia

Cross sectional surveys (2002-2004) achieved in 89 villages, carried on 5474 cattle and 1908 tse tse flies (G. palpalis: 53%; G. tachinoides: 45% and G. morsitans: 2%) have been captured. Following these investigations, several suspected villages have been chosen for longitudinal surveys in order...


Talaki, E.Sidibe, I.Diall, O.Grace, DeliaBarry, A.M.Djiteye, A.Bocoum, Z.Clausen, P.H.Randolph, Thomas F.Affognon, Hippolyte D.Hendrickx, G.Pangui, L.J.Belem, A.M.G.[Répartition spatiale des trypanosomoses animales en relation avec la chimiorésistance dans la zone cotonnière de l’Afrique de l’Ouest (Mali et Guinée)]Répartition spatiale des trypanosomoses animales en relation avec la chimiorésistance dans la zone cotonnière de l’Afrique de l’Ouest (Mali et Guinée)

In a cross-sectional study carried out in June 1994, 486 cattle from 50 randomly selected dairy farms in the vicinity of Kampala, Uganda, were examined for trypanosome infections. The trypanosome prevalence (either positive with the haematocrit centrifugation technique [HCT] and/or the mini-anion...


Clausen, P.H.Schares, G.Patzelt, R.J.Poetzsch, C.J.Scheer, A.Kakaire, D.Olila, D.Peregrine, A.S.McDermott, John J.Mehlitz, D.[PCR and DNA-probe hybridization to assess the efficacy of therapeutic and prophylactic isometamidium treatment in Trypanosoma spp. - infected dairy cattle in peri-urban Kampala, Uganda]PCR and DNA-probe hybridization to assess the efficacy of therapeutic and prophylactic isometamidium treatment in Trypanosoma spp. - infected dairy cattle in peri-urban Kampala, Uganda

Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...


Eisler, M.C.Brandt, J.Bauer, B.Clausen, P.H.Delespaux, V.Holmes, P.H.Ilemobade, A.Machila, N.Mbwambo, H.McDermott, John J.Mehlitz, D.Murilla, G.Ndung'u, J.M.Peregrine, A.S.Sidibe, I.Sinyangwe, L.Geerts, S.[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle

Using a novel multilocus DNA marker analysis method, we studied the population genetic structure of Trypansoma brucei stocks and derived clones isolated from animal and rhodesiense sleeping sickness patients during a national sleeping sickness control program in Mukono district, Uganda. We then ...


Agbo, E.C.Clausen, P.H.Buscher, P.Majiwa, P.A.O.Claassen, E.Marinus, F.W.P.[Population genetic structure and cladistic analysis of Trypanosoma brucei isolates]Population genetic structure and cladistic analysis of Trypanosoma brucei isolates

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