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There is an alarming rate of human African trypanosomiasis recrudescence in many parts of sub-Saharan Africa. Yet, the disease has no successful chemotherapy. Trypanosoma lacks the enzymatic machinery for the de novo synthesis of purine nucleotides, and is critically dependent on salvage mechanis...


Tomoaki BesshoShoko MoriiToshihide KusumotoTakahiro ShinoharaMasanori NodaSusumu UchiyamaSatoshi ShutoShigenori NishimuraShigenori NishimuraDuszenko, M.Martin, S.K.Takashi InuiKubata, K.B.[Characterization of the novel Trypanosoma brucei inosine 5′-monophosphate dehydrogenase]Characterization of the novel Trypanosoma brucei inosine 5′-monophosphate dehydrogenase

Phylogenetic analyses based on defined proteins or different RNA species have revealed that the order kinetoplastida belongs to the early‐branching eukaryotes and may thus contain organisms in which complex cellular events are easier to analyze. This view was further supported by results from a b...


Denninger, V.Koopmann, R.Muhammad, K.Barth, T.Bassarak, B.Schonfeld, C.Kilunga, B.K.Duszenko, M.[Chapter twenty‐five kinetoplastida: Model organisms for simple autophagic pathways?]Chapter twenty‐five kinetoplastida: Model organisms for simple autophagic pathways?
Selzer, P.M.Webster, P.Duszenko, M.[Influence of Ca2+ depletion on cytoskeleton and nucleolus morphology in Trypanosoma brucei]Influence of Ca2+ depletion on cytoskeleton and nucleolus morphology in Trypanosoma brucei

Prostaglandins (PGs) comprise a family of structurally related bioactive lipid mediators that are involved in various symptoms associated with parasitic diseases. The molecular mechanisms of PG biosynthesis in animals have been studied extensively. Currently, several lines of evidence link their ...


Kubata, B.K.Duszenko, M.Martin, K.S.Urade, Y.[Molecular basis for prostaglandin production in hosts and parasites]Molecular basis for prostaglandin production in hosts and parasites

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