The research objective was to develop a thermostable vaccine against peste des petits ruminants (PPR), a morbilliviral disease of small ruminants targeted for eradication that is a major constraint on the livelihoods of the rural poor throughout much of Africa and Asia. Although existing PPR vacc...
Mariner, Jeffrey C.
,
Gachanja, J.
,
Tindih, H.S.
,
Toye, Philip G.
,
[A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia]
,
A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia
Previous studies using monoclonal antibody (mAb) 4C9 specific for a 32 kDa antigen (p32) of Theileria parva demonstrated expression of the antigen on the surface of the sporozoite, making it a potential antigen for sporozoite neutralization. A full-length cDNA encoding the major merozoite/piropla...
Skilton, Robert A.
,
Musoke, A.J.
,
Wells, C.W.
,
Yagi, Y.
,
Nene, Vishvanath
,
Spooner, P.R.
,
Gachanja, J.
,
Osaso, J.
,
Bishop, Richard P.
,
Morzaria, S.P.
,
[A 32 kDa surface antigen of Theileria parva: Characterization and immunization studies]
,
A 32 kDa surface antigen of Theileria parva: Characterization and immunization studies
Theileria parva antigens recognized by cytotoxic T lymphocytes (CTLs) are prime vaccine candidates against East Coast Fever in cattle. A strategy for enhancing induction of parasite-specific T cell responses by increasing recruitment and activation of dendritic cells (DCs) at the immunization sit...
Mwangi, D.M.
,
Honda, Y.
,
Graham, S.P.
,
Pelle, Roger
,
Taracha, E.L.N.
,
Gachanja, J.
,
Nyanjui, J.K.
,
Bray, J.
,
Palmer, G.H.
,
Brown, W.C.
,
Mwangi, W.
,
[Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses]
,
Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses