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A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...


Koudande, O.D.Thomson, P.C.Bovenhuis, H.Iraqi, F.A.Gibson, John P.Arendonk, Johan A.M. van[Biphasic survival analysis of trypanotolerance QTL in mice]Biphasic survival analysis of trypanotolerance QTL in mice

The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsib...


Behnke, J.M.Iraqi, F.A.Menge, D.Baker, R.L.Gibson, John P.Wakelin, D.[Chasing the genes that control resistance to gastrointestinal nematodes]Chasing the genes that control resistance to gastrointestinal nematodes

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...


Behnke, J.M.Mugambi, J.M.M.Clifford, S.Iraqi, F.A.Baker, R.L.Gibson, John P.Wakelin, D.[Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project]Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project

Bayesian segregation analysis using a Gibbs sampling approach was applied to four sets of simulated data and one set of field data to detect evidence of major genes affecting the evaluated trait. The substitution effect of a major gene and its allelic frequency were estimated for each set of data...


Pan, Y.Boettcher, P.J.Gibson, John P.[Bayesian segregation analysis of somatic cell scores of ontario Holstein cattle]Bayesian segregation analysis of somatic cell scores of ontario Holstein cattle

A resource population of 429 pigs was developed from crosses of Hampshire, Duroc and Large White breeds ((H x D) x LW) for detection of quantitative trait loci (QTLs). Associations of histone deacetylase (HDAC) and fatty acid binding protein (FABP) candidate genes with 110 growth, carcass and mea...


Ye, X.Robinson, J.A.B.Jiang, Z.Gibbins, A.M.V.Gibson, John P.[Polymorphisms of histone deacetylase 1 and 3 genes and fatty acid binding protein 3 and 4 genes and their associations with economic traits in swine]Polymorphisms of histone deacetylase 1 and 3 genes and fatty acid binding protein 3 and 4 genes and their associations with economic traits in swine

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