Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...
Kitani, H.
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Black, S.J.
,
Nakamura, Y.
,
Naessens, Jan
,
Murphy, N.
,
Yokomizo, Y.
,
Gibson, John P.
,
Iraqi, F.A.
,
[Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures]
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Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures
To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-d...
O'Gorman, G.M.
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Park, S.D.E.
,
Hill, E.W.
,
Meade, K.G.
,
Mitchell, L.C.
,
Agaba, Morris
,
Gibson, John P.
,
Hanotte, Olivier H.
,
Naessens, Jan
,
Kemp, Stephen J.
,
MacHugh, D.E.
,
[Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense]
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Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense
The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to Trypanosoma congolense infection. To evaluate whether the HSP70.1 gene is involved in the response, we compared the susceptibility of HS...
Nakamura, Y.
,
Naessens, Jan
,
Takata, M.
,
Taniguchi, T.
,
Sekikawa, K.
,
Gibson, John P.
,
Iraqi, F.A.
,
[Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection]
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Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection
An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in bo...
Kemp, Stephen J.
,
Hanotte, Olivier H.
,
Agaba, Morris
,
Noyes, H.A.
,
Gibson, John P.
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Archibald, A.L.
,
Rennie, C.
,
Hulme, H.
,
Brass, A.
,
[Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons]
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Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons
Menge, D.
,
Behnke, J.
,
Lowe, A.
,
Gibson, John P.
,
Baker, L.
,
Wakelin, D.
,
Iraqi, F.A.
,
[Mapping of QTL influencing immunological responses to gastrointestinal nematode infection in mice. Abstract]
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Mapping of QTL influencing immunological responses to gastrointestinal nematode infection in mice. Abstract
Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...
Menge, D.M.
,
Behnke, J.M.
,
Iraqi, F.A.
,
Lowe, A.
,
Teale, A.J.
,
Gibson, John P.
,
Wakelin, D.
,
Baker, R.L.
,
[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]
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Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice
Ng'ang'a, J.
,
Gibson, John P.
,
Imbuga, J.
,
Kemp, Stephen J.
,
Iraqi, F.A.
,
[Towards fine mapping trypanosomiasis resistance QTL Tir 2 and 3 using F12 Tir1 depleted advanced intercross line population. Abstract]
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Towards fine mapping trypanosomiasis resistance QTL Tir 2 and 3 using F12 Tir1 depleted advanced intercross line population. Abstract
Kierstein, S.
,
Noyes, H.A.
,
Nakamura, Y.
,
Naessens, Jan
,
Kemp, Stephen J.
,
Iraqi, F.A.
,
Gibson, John P.
,
[Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract]
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Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract
Nakamura, Y.
,
Tsuchiya, Y.
,
Naessens, Jan
,
Gibson, John P.
,
Iraqi, F.A.
,
[Glucocorticoid responses to Trypanosoma congolense infection in susceptible and resistance mouse strains. Abstract]
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Glucocorticoid responses to Trypanosoma congolense infection in susceptible and resistance mouse strains. Abstract
Iraqi, F.A.
,
Menge, D.M.
,
Behnke, J.M.
,
Lowe, A.
,
Teale, A.J.
,
Gibson, John P.
,
Baker, L.R.
,
Wakelin, D.
,
[Detection of QTL for resistance to gastrointestinal nematode infection in mice. Abstract]
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Detection of QTL for resistance to gastrointestinal nematode infection in mice. Abstract