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Trypanosomes are covered with a dense layer of antigenically identical glycoproteins. These molecules are highly immunogenic and elicit an antibody response in the infected host. Antibodies against the surface-exposed epitopes of the trypanosome variable surface glycoproteins (VSG) mediate the de...


Williams, D.J.L.Taylor, K.Wilkie, B.Gichuki, B.Authié, E.[Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle]Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle

It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exp...


Williams, D.J.L.Taylor, K.Newson, J.Gichuki, B.Naessens, Jan[The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance]The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance

Trypanosomiasis is a serious constraint to livestock production in sub-Saharan Africa. Some breeds of cattle are genetically more resistant to the pathogenic effects of trypanosome infection. We measured B-cell activation and the quantity and isotype of antibody produced at the cellular level in ...


Taylor, K.A.Lutje, V.Kennedy, D.Authié, E.Boulange, A.F.Logan-Henfrey, L.L.Gichuki, B.Gettinby, G.[Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle]Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle

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