Theileria parva, a tick-transmitted protozoan parasite, infects cattle in eastern, central and southern Africa, leading to an acute, usually fatal lymphoproliferative disorder known as East Coast fever (1). It has been shown that the protective immune response against T. parva is mediated by clas...
Daubenberger, C.A.
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Heussler, V.
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Gobright, E.I.
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Wijngaard, P.L.J.
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Clevers, H.C.
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Wells, C.
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Tsuji, N.
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Musoke, A.J.
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McKeever, Declan J.
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[Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan parasite Theileria parva]
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Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan parasite Theileria parva
Kibe, M.K.
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Ole-MoiYoi, O.K.
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Nene, Vishvanath
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Khan, B.
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Allsopp, B.A.
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Collins, N.E.
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Morzaria, S.P.
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Gobright, E.I.
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Bishop, B.P.
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[Evidence for two single copy units in Theileria parva ribosomal RNA genes]
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Evidence for two single copy units in Theileria parva ribosomal RNA genes
A stage-specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in cattle. By Pepscan analysis with a series of overlapping synthetic p67 peptides, the antigen was shown to contain five distinct lin...
Nene, Vishvanath
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Gobright, E.I.
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Bishop, Richard P.
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Morzaria, S.P.
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Musoke, A.J.
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[Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralising epitopes: Implications for a vaccine]
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Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralising epitopes: Implications for a vaccine
Immunity to Theileria parva infection in cattle is often parasite stock specific. The antigenic diversity which is expressed at the schizont stage of the parasite together with a wild reservoir of the organism in buffalo has complicated the development of effective disease control by immunization...
Nene, Vishvanath
,
Musoke, A.J.
,
Gobright, E.I.
,
Morzaria, S.P.
,
[Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles]
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Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles