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The sensitivity of seven populations of T. congolense to the salts of three trypanocides, diminazene, isometamidium and homidium, were determined in vitro using in vitro-derived metacyclic trypanosomes. The trypanosomes were incubated at 35 degree centigrade for 48 hours with various drug concent...


Gray, M.A.Peregrine, A.S.[An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes]An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes
Zweygarth, E.Gumm, I.D.Gray, M.A.Cheruiyot, J.K.Webster, P.Kaminsky, R.[In vitro development of metacyclic Trypanosoma simiae derived from bloodstream trypomastigotes]In vitro development of metacyclic Trypanosoma simiae derived from bloodstream trypomastigotes
Zweygarth, E.Moloo, S.K.Kaminsky, R.Gray, M.A.[Axenic in vitro cultivation of Trypanosoma simiae bloodstream trypomastigote]Axenic in vitro cultivation of Trypanosoma simiae bloodstream trypomastigote
Zweygarth, E.Kaminsky, R.Gray, M.A.[In vitro assessment of isometamidium chloride susceptibility of Trypanosoma vivax bloodstream forms]In vitro assessment of isometamidium chloride susceptibility of Trypanosoma vivax bloodstream forms
Zweygarth, E.Gray, M.A.Kaminsky, R.[Axenic in vitro cultivation of Trypanosoma vivax trypomastigote forms]Axenic in vitro cultivation of Trypanosoma vivax trypomastigote forms
Silayo, R.S.Mamman, M.Moloo, S.K.Aliu, Y.O.Gray, M.A.Peregrine, A.S.[Response of Trypanosoma congolense in goats to single and double treatment with diminazene aceturate]Response of Trypanosoma congolense in goats to single and double treatment with diminazene aceturate
Gray, M.A.Kimarua, R.W.Peregrine, A.S.[Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya]Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya

Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectivel...


Peregrine, A.S.Gray, M.A.Moloo, S.K.[Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense]Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense

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