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Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the ef...


Hernández Valladares, M.Naessens, JanIraqi, F.A.[Gene-knockout mice in malaria research: Useful or misleading?]Gene-knockout mice in malaria research: Useful or misleading?

Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have i...


Hernández Valladares, M.Naessens, JanIraqi, F.A.[Genetic resistance to malaria in mouse models]Genetic resistance to malaria in mouse models

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