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Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the ef...


Hernández Valladares, M.Naessens, JanIraqi, F.A.[Gene-knockout mice in malaria research: Useful or misleading?]Gene-knockout mice in malaria research: Useful or misleading?

We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falc...


Flori, L.Delahaye, N.F.Iraqi, F.A.Hernández Valladares, M.Fumoux, F.Rihet, P.[TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso]TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso

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