A survey to investigate resistance to drugs used in the treatment of bovine trypanosomosis was conducted in the eastern province of Zambia between 1996 and 1998. A cross-sectional study was conducted in three districts (Petauke, Katete, Lundazi) at 34 village sampling sites selected at random fr...
Sinyangwe, L.
,
Delespaux, V.
,
Brandt, J.
,
Geerts, S.
,
Mubanga, J.
,
Machila, N.
,
Holmes, P.H.
,
Eisler, M.C.
,
[Trypanocidal drug resistance in eastern province of Zambia]
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Trypanocidal drug resistance in eastern province of Zambia
Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognize...
Peregrine, A.S.
,
Eisler, M.C.
,
Katende, J.
,
Flynn, J.N.
,
Gault, E.A.
,
Kinabo, L.D.B.
,
Holmes, P.H.
,
[Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium]
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Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium
Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...
Eisler, M.C.
,
Brandt, J.
,
Bauer, B.
,
Clausen, P.H.
,
Delespaux, V.
,
Holmes, P.H.
,
Ilemobade, A.
,
Machila, N.
,
Mbwambo, H.
,
McDermott, John J.
,
Mehlitz, D.
,
Murilla, G.
,
Ndung'u, J.M.
,
Peregrine, A.S.
,
Sidibe, I.
,
Sinyangwe, L.
,
Geerts, S.
,
[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]
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Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle
Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalenc...
Eisler, M.C.
,
McDermott, John J.
,
Mdachi, R.
,
Murilla, G.
,
Sinyangwe, L.
,
Mubanga, J.
,
Machila, N.
,
Mbwambo, H.
,
Coleman, P.G.
,
Clausen, P.H.
,
Bauer, B.
,
Sidibe, I.
,
Geerts, S.
,
Holmes, P.H.
,
Peregrine, A.S.
,
[Rapid method for the assessment of trypanocidal drug resistance in the field]
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Rapid method for the assessment of trypanocidal drug resistance in the field