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A survey to investigate resistance to drugs used in the treatment of bovine trypanosomosis was conducted in the eastern province of Zambia between 1996 and 1998. A cross-sectional study was conducted in three districts (Petauke, Katete, Lundazi) at 34 village sampling sites selected at random fr...


Sinyangwe, L.Delespaux, V.Brandt, J.Geerts, S.Mubanga, J.Machila, N.Holmes, P.H.Eisler, M.C.[Trypanocidal drug resistance in eastern province of Zambia]Trypanocidal drug resistance in eastern province of Zambia

Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognize...


Peregrine, A.S.Eisler, M.C.Katende, J.Flynn, J.N.Gault, E.A.Kinabo, L.D.B.Holmes, P.H.[Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium]Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium

Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...


Eisler, M.C.Brandt, J.Bauer, B.Clausen, P.H.Delespaux, V.Holmes, P.H.Ilemobade, A.Machila, N.Mbwambo, H.McDermott, John J.Mehlitz, D.Murilla, G.Ndung'u, J.M.Peregrine, A.S.Sidibe, I.Sinyangwe, L.Geerts, S.[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle

Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalenc...


Eisler, M.C.McDermott, John J.Mdachi, R.Murilla, G.Sinyangwe, L.Mubanga, J.Machila, N.Mbwambo, H.Coleman, P.G.Clausen, P.H.Bauer, B.Sidibe, I.Geerts, S.Holmes, P.H.Peregrine, A.S.[Rapid method for the assessment of trypanocidal drug resistance in the field]Rapid method for the assessment of trypanocidal drug resistance in the field

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