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The development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R; BALB/c and DBA/2) and CM-susceptible (CM-S; C57BL/6 and CBA/J) mice by use of cDNA mic...


Delhaye, N.F.Coltel, N.Puthier, D.Flori, L.Houlgatte, R.Iraqi, F.A.Nguyen, C.Grau, G.E.Rihet, P.[Gene-expression profiling discriminates between cerebral malaria (CM) - susceptible mice and CM-resistant mice]Gene-expression profiling discriminates between cerebral malaria (CM) - susceptible mice and CM-resistant mice

In view of the Tnfa gene location within the major histocompatibility (MHC) region and reports of its importance in disease protection activity, this paper examines the TNF a genes of a number of different mouse strains which were known to be of different disease response phenotypes. Twelve inbre...


Iraqi, F.A.Teale, A.J.[Polymorphisms, in the Tnfa gene of different inbred mouse strains]Polymorphisms, in the Tnfa gene of different inbred mouse strains

To optimize designs to implement marker-assisted introgression programs aiming to introgress three unlinked quantitative trait loci (QTL), the present paper studies different alternatives versus a traditional backcross or intercross phase. Four alternative backcross strategies appear to be more a...


Koudande, O.D.Iraqi, F.A.Thomson, P.C.Teale, A.J.Arendonk, Johan A.M. van[Strategies to optimize marker-assisted introgression of multiple unlinked QTL]Strategies to optimize marker-assisted introgression of multiple unlinked QTL
Autor: Iraqi, F.A.

High-resolution mapping of quantitative trait loci (QTLs) is an essential step towards positional cloning and identification of the corresponding genes. Most QTL detection and mapping studies in mice have been carried out using F2 intercross and backcross populations. As a consequence of the limi...


Iraqi, F.A.[Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes]Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes

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