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Shiga toxin-producing Escherichia coli (STEC) cause gastrointestinal illnesses including non-bloody or bloody diarrhoea, haemorrhagic colitis (HC), and the haemolytic uremic syndrome (HUS). To investigate the occurrence of STEC among grazing dromedaries from Kenya, E. coli isolated from fecal mat...


Baschera, M.Cernela, N.Stevens, M.J.A.Liljander, Anne M.Jores, JoergMax Corman, V.Nüesch-Inderbinen, M.Stephan, R.[Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels]Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essent...


Jores, JoergMa, L.Ssajjakambwe, PaulSchieck, Elise G.Liljander, Anne M.Chandran, S.Stoffel, M.H.Cippa, V.Arfi, Y.Assad-Garcia, N.Falquet, L.Sirand-Pugnet, P.Blanchard, AlainLartigue, C.Posthaus, H.Labroussaa, F.Vashee, S.[Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain]Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain

Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenesis. Th...


Lartigue, C.Valverde Timana, Y.Labroussaa, F.Schieck, Elise G.Liljander, Anne M.Sacchini, FlavioPosthaus, H.Batailler, B.Sirand-Pugnet, P.Vashee, S.Jores, JoergBlanchard, Alain[Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches]Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches

Awino, EliasAye, R.Bertrand, S.Gesharisha, J.Gicheru, N.Jores, JoergLiljander, Anne M.Muriuki, C.Naessens, JanNene, VishvanathNjoroge, T.Nyongesa, S.Pelle, RogerSsajjakambwe, P.Saya, R.Schieck, Elise G.Steinaa, LucillaSvitek, NicholasWasilwa, J.[ILRI vaccine biosciences—Planting the orchard: (ILRI’s Vaccine Platform‐ILVAC)]ILRI vaccine biosciences—Planting the orchard: (ILRI’s Vaccine Platform‐ILVAC)

Mycoplasma mycoides subsp. mycoides SC is the pathogenic agent of contagious bovine pleuropneumonia (CBPP), the most important disease of cattle in Africa causing significant economic losses. The re-emergence of CBPP in Europe in the 1980s and 1990s illustrates that it is still a threat also to c...


Schnee, C.Heller, M.Jores, JoergTomaso, H.Neubauer, H.[Assessment of a novel multiplex real-time PCR assay for the detection of the CBPP agent Mycoplasma mycoides subsp. mycoides SC through experimental infection in cattle]Assessment of a novel multiplex real-time PCR assay for the detection of the CBPP agent Mycoplasma mycoides subsp. mycoides SC through experimental infection in cattle

Contagious Bovine Pleuropneumonia caused by Mycoplasma mycoides subsp. mycoides small colony type is a respiratory disease of considerable economic importance in sub-Saharan Africa; control of the disease in Africa is hampered by diagnostic tests which are suited for herd-level but not for indivi...


Naseem, S.Meens, J.Jores, JoergHeller, M.Dabel, S.Hust, M.Gerlach, G.F.[Phage display-based identification and potential diagnostic application of novel antigens from Mycoplasma mycoides subsp. mycoides small colony type]Phage display-based identification and potential diagnostic application of novel antigens from Mycoplasma mycoides subsp. mycoides small colony type

A multilocus sequence typing (MLST) scheme was established and evaluated for Mycoplasma hyopneumoniae, the etiologic agent of enzootic pneumonia in swine with the aim of defining strains. Putative target genes were selected by genome sequence comparisons. Out of 12 housekeeping genes chosen and e...


Mayor, D.Jores, JoergKorczak, B.M.Kuhnert, P.[Multilocus sequence typing (MLST) of Mycoplasma hyopneumoniae: A diverse pathogen with limited clonality]Multilocus sequence typing (MLST) of Mycoplasma hyopneumoniae: A diverse pathogen with limited clonality

Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides, is an important livestock disease in Africa. The current control measures rely on a vaccine with limited efficacy and occasional severe side effects. Knowledge of the protective arms of immunity involved in t...


Sacchini, F.Naessens, JanAwino, EliasHeller, M.Hlinak, A.Haider, W.Sterner-Kock, AnjaJores, Joerg[A minor role of CD4+ T lymphocytes in the control of a primary infection of cattle with Mycoplasma mycoides subsp. Mycoides]A minor role of CD4+ T lymphocytes in the control of a primary infection of cattle with Mycoplasma mycoides subsp. Mycoides

Our understanding of the composition of Escherichia coli populations in wild boars is very limited. In order to obtain insight into the E. coli microflora of wild boars, we studied E. coli isolates from the jejunums, ileums, and colons of 21 wild boars hunted in five geographic locations in Germa...


Schierack, P.Römer, A.Jores, JoergKaspar, H.Guenther, S.Filter, M.Eichberg, J.Wieler, L.H.[Isolation and Characterization of Intestinal Escherichia coli Clones from Wild Boars in Germany]Isolation and Characterization of Intestinal Escherichia coli Clones from Wild Boars in Germany
Schubert, E.Sachse, K.Jores, JoergHeller, M.[Serological testing of cattle experimentally infected with Mycoplasma mycoides subsp. mycoides Small Colony using four different tests reveals a variety of seroconversion patterns]Serological testing of cattle experimentally infected with Mycoplasma mycoides subsp. mycoides Small Colony using four different tests reveals a variety of seroconversion patterns

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