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A new hepatitis E virus (HEV-7) was recently found in dromedaries and 1 human from the United Arab Emirates. We screened 2,438 dromedary samples from Pakistan, the United Arab Emirates, and 4 African countries. HEV-7 is long established, diversified and geographically widespread. Dromedaries may ...


Rasche, A.Saqib, M.Liljander, Anne M.Bornstein, S.Zohaib, A.Renneker, S.Steinhagen, K.Wernery, R.Younan, M.Gluecks, Ilona V.Hilali, M.Musa, B.E.Jores, JoergWernery, U.Drexer, J.F.Drosten, C.Corman, V.M.[Hepatitis E virus infection in dromedaries, North and East Africa, United Arab Emirates, and Pakistan, 1983–2015]Hepatitis E virus infection in dromedaries, North and East Africa, United Arab Emirates, and Pakistan, 1983–2015

Camels are the most valuable livestock species in the Horn of Africa and play a pivotal role in the nutritional sustainability for millions of people. Their health status is therefore of utmost importance for the people living in this region. Streptococcus agalactiae, a Group B Streptococcus (GBS...


Fischer, A.Liljander, Anne M.Kaspar, H.Muriuki, C.Fuxelius, H.H.Bongcam-Rudloff, E.Villiers, Etienne P. deHuber, C.A.Frey, J.Daubenberger, C.A.Bishop, Richard P.Younan, M.Jores, Joerg[Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element]Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element

Contagious bovine pleuropneumonia (CBPP) is a cattle disease that has hampered the development of the livestock sector in sub-Saharan Africa. Currently, vaccination with a live vaccine strain is its recommended control measure although unofficial antimicrobial use is widely practiced. Here, model...


Ssematimba, A.Jores, JoergMariner, Jeffrey C.[Mathematical modelling of the transmission dynamics of contagious bovine pleuropneumonia reveals minimal target profiles for improved vaccines and diagnostic assays]Mathematical modelling of the transmission dynamics of contagious bovine pleuropneumonia reveals minimal target profiles for improved vaccines and diagnostic assays

The ‘Mycoplasma mycoides cluster’ comprises the ruminant pathogens Mycoplasma mycoides subsp. mycoides the causative agent of contagious bovine pleuropneumonia (CBPP), Mycoplasma capricolum subsp. capripneumoniae the agent of contagious caprine pleuropneumonia (CCPP), Mycoplasma capricolum subsp....


Fischer, A.Shapiro, Barry I.Muriuki, C.Heller, M.Schnee, C.Bongcam-Rudloff, E.Frey, J.Jores, Joerg[The origin of the Mycoplasma mycoides cluster coincides with domestication of ruminants]The origin of the Mycoplasma mycoides cluster coincides with domestication of ruminants

Five Mycoplasma strains from wild Caprinae were analyzed: four from Alpine ibex (Capra ibex) which died at the Berlin Zoo between 1993 and 1994, one from a Rocky Mountain goat collected in the USA prior to 1987. These five strains represented a population different from the populations belonging ...


Jores, JoergFischer, A.Sirand-Pugnet, P.Thomann, A.Liebler-Tenorio, E.M.Schnee, C.Santana-Cruz, I.Heller, M.Frey, J.[Mycoplasma feriruminatoris sp. nov., a fast growing Mycoplasma species isolated from wild Caprinae]Mycoplasma feriruminatoris sp. nov., a fast growing Mycoplasma species isolated from wild Caprinae

Current contagious bovine pleuropneumonia (CBPP) vaccines are based on live-attenuated strains of Mycoplasma mycoides subsp. mycoides (Mmm). These vaccines have shortcomings in terms of efficacy, duration of immunity and in some cases show severe side effects at the inoculation site; hence the ne...


Pérez Casal, J.Prysliak, T.Maina, T.Wang, Y.Townsend, H.Berverov, E.Nkando, I.Wesonga, H.O.Liljander, Anne M.Jores, JoergNaessens, JanGerdts, V.Potter, A.[Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia]Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia

To analyze the distribution of Middle East respiratory syndrome coronavirus (MERS-CoV)–seropositive dromedary camels in eastern Africa, we tested 189 archived serum samples accumulated during the past 30 years. We identified MERS-CoV neutralizing antibodies in 81.0% of samples from the main camel...


Muller, M.A.Corman, V.M.Jores, JoergMeyer, B.Younan, M.Liljander, Anne M.Bosch, B.J.Lattwein, E.Hilali, M.Musa, B.E.Bornstein, S.Drosten, C.[MERS coronavirus neutralizing antibodies in camels, eastern Africa, 1983-1997]MERS coronavirus neutralizing antibodies in camels, eastern Africa, 1983-1997

Contagious Bovine Pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides, is widespread in sub-Saharan Africa. The current live vaccine T1/44 has limited efficacy and occasionally leads to severe side effects in the animals. A better understanding of the immune responses triggered ...


Sacchini, F.Luciani, M.Salini, R.Scacchia, M.Pini, A.Lelli, R.Naessens, JanPoole, Elizabeth J.Jores, Joerg[Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia]Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia

With the development of several new technologies using synthetic biology, it is possible to engineer genetically intractable organisms including Mycoplasma mycoides subspecies capri (Mmc), by cloning the intact bacterial genome in yeast, using the host yeast’s genetic tools to modify the cloned g...


Chandran, S.Noskov, V.N.Segall-Shapiro, T.H.Ma, L.Whiteis, C.Lartigue, C.Jores, JoergVashee, S.Ray-Yuan Chuang[TREC-IN: gene knock-in genetic tool for genomes cloned in yeast]TREC-IN: gene knock-in genetic tool for genomes cloned in yeast

Background: Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP), a respiratory disease of cattle, whereas the closely related Mycoplasma mycoides subsp. capri (Mmc) is a goat pathogen. Cyto-adherence is a crucial step in host colonization b...


Aye, R.Mwirigi, M.K.Frey, J.Pilo, P.Jores, JoergNaessens, Jan[Cyto-adherence of Mycoplasma mycoides subsp. mycoides to bovine lung epithelial cells]Cyto-adherence of Mycoplasma mycoides subsp. mycoides to bovine lung epithelial cells

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