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Differences in gene expression may be caused by nearby DNA polymorphisms (cis regulation) or by interactions of gene control regions with polymorphic transcription factors (trans regulation). Trans acting loci are much harder to detect than cis acting loci and their effects are much more sensitiv...


Noyes, H.A.Agaba, MorrisAnderson, S.Archibald, A.L.Brass, A.Gibson, John P.Hall, L.Hulme, H.Oh, S.J.Kemp, Stephen J.[Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background]Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background

An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in bo...


Kemp, Stephen J.Hanotte, Olivier H.Agaba, MorrisNoyes, H.A.Gibson, John P.Archibald, A.L.Rennie, C.Hulme, H.Brass, A.[Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons]Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons
Bett, Bernard K.Kiplimo, Jusper RonohNotenbaert, An Maria OmerKemp, Stephen J.[Mapping the distribution of potential Rift Valley fever hotspots in East Africa]Mapping the distribution of potential Rift Valley fever hotspots in East Africa
Iraqi, F.A.Hanotte, Olivier H.Baker, L.Mugambi, J.Leonard, A.K.Orenge, M.C.Soller, M.Kemp, Stephen J.Gibson, John P.[Genomics and breeding for highly productive and disease resistance livestock in the tropics]Genomics and breeding for highly productive and disease resistance livestock in the tropics

This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...


Kierstein, S.Noyes, H.Naessens, JanNakamura, Y.Pritchard, J.Gibson, John P.Kemp, Stephen J.Brass, A.[Gene expression profiling in a mouse model for African trypanosomiasis]Gene expression profiling in a mouse model for African trypanosomiasis

Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...


Kemp, Stephen J.Teale, A.J.[Genetic basis of trypanotolerance in cattle and mice]Genetic basis of trypanotolerance in cattle and mice

It is increasingly common to combine genome-wide expression data with quantitative trait mapping data to aid in the search for sequence polymorphisms responsible for phenotypic variation. By joining these complex but different data types at the level of the biological pathway, we can take advanta...


Fisher, P.Noyes, H.Kemp, Stephen J.Stevens, R.Brass, A.[A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation]A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens...


Behnke, J.M.Menge, D.M.Nagda, S.M.Noyes, H.Iraqi, F.A.Kemp, Stephen J.Mugambi, R.J.M.Baker, R.L.Wakelin, D.Gibson, John P.[Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice]Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

Fine mapping of quantitative trait loci (QTL) associated with resistance to the gastrointestinal parasite Heligmosomoides polygyrus was achieved on F6/F7 offspring (1076 mice) from resistant (SWR) and susceptible (CBA) mouse strains by selective genotyping (top and bottom 20% selected on total wo...


Behnke, J.M.Iraqi, F.A.Mugambi, J.M.M.Clifford, S.Nagda, S.M.Wakelin, D.Kemp, Stephen J.Leyden, B.Gibson, John P.[High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice]High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice

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