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African animal trypanosomiasis (AAT) caused by tsetse fly-transmitted protozoa of the genus Trypanosoma is a major constraint on livestock and agricultural production in Africa and is among the top ten global cattle diseases impacting on the poor. Here we show that a functional genomics approach ...


O'Gorman, G.M.Park, S. deHill, E.W.Meade, K.G.Coussens, P.M.Agaba, MorrisNaessens, JanKemp, Stephen J.MacHugh, D.E.[Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility]Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility
Kemp, Stephen J.Maillard, J.C.Teale, A.J.[A polymorphism in the bovine gamma-S-crystallin gene revealed by allele-specific amplification]A polymorphism in the bovine gamma-S-crystallin gene revealed by allele-specific amplification
Agaba, MorrisKemp, Stephen J.[Characterization of the 3' untranslated region of bovine parathyroid hormone gene in N'Dama and Boran cattle]Characterization of the 3' untranslated region of bovine parathyroid hormone gene in N'Dama and Boran cattle

Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...


Kemp, Stephen J.Teale, A.J.[Genetic basis of trypanotolerance in cattle and mice]Genetic basis of trypanotolerance in cattle and mice

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localization of genes controlling resistance to trypanosomiasis in mice]Localization of genes controlling resistance to trypanosomiasis in mice
Bensaid, A.M.Naessens, JanKemp, Stephen J.Black, S.J.Shapiro, S.Z.Teale, A.J.[An immunochemical analysis of class I (BoLA) molecules on the surface of bovine cells]An immunochemical analysis of class I (BoLA) molecules on the surface of bovine cells
Bensaid, A.M.Kaushal, D.Baldwin, C.L.Clevers, H.Young, J.R.Kemp, Stephen J.MacHugh, Niall D.Toye, Philip G.Teale, A.J.[Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage]Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage

A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populati...


Teale, A.J.Agaba, MorrisClapcott, S.J.Gelhaus, A.Haley, C.Psifidis, A.Horstmann, R.Iraqui, F.Kemp, Stephen J.Nilsson, P.Schwerin, M.Sekikawa, K.Soller, M.Sugimoto, Y.Womack, J.[Resistance to trypanosomosis: Of markers, genes and mechanisms]Resistance to trypanosomosis: Of markers, genes and mechanisms

The cartography in the high resolution of quantitative locus of character (QTL) is an important step towards the positional cloning or the positional identification of candidate genes. Recently, the use of descendants at the advanced inter-junction has been described for the dissection and the pr...


Iraqi, F.A.Kemp, Stephen J.Teale, A.J.[Towards identification and cloning of the trypanotolerance genes in mouse]Towards identification and cloning of the trypanotolerance genes in mouse

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