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Human chromosome (Chr) 18(HSA 18) contains approximately 85 million base pains of DNA. Thirty genes and pseudogenes have been mapped to HSA 18 by somatic cell genetics or in situ hybridization. Two bovine genes - Yamaguchi sacroma viral oncogene homology 1 (YESI) and desmocollin type 1 (DSC1) - h...


Agaba, MorrisKemp, Stephen J.Barendse, W.Teale, A.J.[Comparative mapping in cattle of genes located on human chromosome 18]Comparative mapping in cattle of genes located on human chromosome 18

A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...


Nilsson, P.H.Kang'a, S.Rottengatter, K.Suedbeck, U.Iraqui, F.Mwakaya, J.Mwangi, D.Womack, J.E.Goldammer, T.Schwerin, M.Bradley, D.Agaba, MorrisSugimoto, K.Gelhaus, A.Horstmann, R.Teale, A.J.Kemp, Stephen J.Hanotte, Olivier H.[Radiation hybrid maps of candidate trypanotolerance regions in cattle]Radiation hybrid maps of candidate trypanotolerance regions in cattle

We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...


Park, S.D.E.Adomefa, K.Dao, B.Hanotte, Olivier H.Kemp, Stephen J.Sow, R.S.Teale, A.J.Bradley, D.G.[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance

Background: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards understanding the genomic basis of productivity and adaptation to s...


Kim, JaeminHanotte, Olivier H.Okeyo Mwai, AllyDessie, TadelleSalim, BashirDiallo, BoubacarAgaba, MorrisKwondo KimWoori KwakSamsun SungSeo, MinseokJeong, HyeonsooKwon, TaehyungTaye, MengistieSong, Ki-DukLim, DajeongSeoae ChoLee, Hyun-JeongDuhak YoonSung Jong OhKemp, Stephen J.Hak-Kyo LeeHeebal Kim[The genome landscape of indigenous African cattle]The genome landscape of indigenous African cattle

West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...


Naessens, JanLeak, S.G.A.Kennedy, D.J.Kemp, Stephen J.Teale, A.J.[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
Kemp, Stephen J.Maillard, J.C.Teale, A.J.[A polymorphism in the bovine gamma-S-crystallin gene revealed by allele-specific amplification]A polymorphism in the bovine gamma-S-crystallin gene revealed by allele-specific amplification

A report of the first workshop on the genetic map of bovine chromosome 1 (BTA1) is presented. Five laboratories contributed 31 962 informative meioses from 70 loci. Thirty-two loci which had been typed by at least two laboratories were used to construct a framework genetic map with a likelihood r...


Taylor, J.F.Brenneman, R.A.Burns, B.M.Davis, S.K.Yeh, C.C.Bishop, M.D.Eggen, A.Vaiman, D.Aleyasin, A.Armitage, S.M.Barendse, W.Beever, J.E.Lewin, H.A.Ma, R.Z.Elo, K.Vilkki, J.Harlizius, B.Kappes, S.M.Keele, J.W.Stone, R.T.Kemp, Stephen J.Kirkpatrick, B.W.McGraw, R.A.Pomp, D.Sugimoto, Y.Teale, A.J.Williams, J.L.Zanotti, M.C.[Report of the first workshop on the genetic map of bovine chromosome 1]Report of the first workshop on the genetic map of bovine chromosome 1

High levels of inbreeding in East African dairy cattle are a potential concern because of use of a limited range of imported germplasm coupled with strong selection, especially by disease, and sparse performance recording. To address this, genetic relationships and breed composition in an admixed...


Gorbach, D.M.Makgahlela, M.L.Reecy, J.M.Kemp, Stephen J.Baltenweck, IsabelleOuma, R.Okeyo Mwai, AllyMarshall, KarenMurdoch, B.Moore, S.Rothschild, Max F.[Use of SNP genotyping to determine pedigree and breed composition of dairy cattle in Kenya]Use of SNP genotyping to determine pedigree and breed composition of dairy cattle in Kenya

High-through put technologies inevitably produce vast quantities of data. This presents challenges in terms of developing effective analysis methods, particularly where the analysis involves combining data derived from different experimental technologies. In this investigation, a systematic appro...


Rennie, C.Hulme, H.Fisher, P.Halp, L.Agaba, MorrisNoyes, H.A.Kemp, Stephen J.Brass, A.[A systematic, data-driven approach to the combined analysis of microarray and QTL data]A systematic, data-driven approach to the combined analysis of microarray and QTL data

Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and...


Hanotte, Olivier H.Ronin, Y.Agaba, MorrisNilsson, P.Gelhaus, A.Horstmann, R.Sugimoto, Y.Kemp, Stephen J.Gibson, John P.Korol, A.Soller, M.Teale, A.J.[Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle]Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle

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