Mycoplasma mycoides subsp. mycoides is the etiologic agent of contagious bovine pleuropneumonia. We report here the complete genome sequence of the strain T1/44, which is widely used as a live vaccine in Africa.
Gourgues, G.
,
Barre, A.
,
Beaudoing, E.
,
Weber, J.
,
Magdelenat, G.
,
Barbe, V.
,
Schieck, Elise G.
,
Jores, Joerg
,
Vashee, S.
,
Blanchard, Alain
,
Lartigue, C.
,
Sirand-Pugnet, P.
,
[Complete genome sequence of Mycoplasma mycoides subsp. mycoides T1/44, a vaccine strain against contagious bovine pleuropneumonia]
,
Complete genome sequence of Mycoplasma mycoides subsp. mycoides T1/44, a vaccine strain against contagious bovine pleuropneumonia
Jores, Joerg
,
Schieck, Elise G.
,
Liljander, Anne M.
,
Sacchini, Flavio
,
Posthaus, H.
,
Lartigue, C.
,
Blanchard, Alain
,
Labroussaa, F.
,
Vashee, S.
,
[In vivo role of capsular polysaccharide in Mycoplasma mycoides]
,
In vivo role of capsular polysaccharide in Mycoplasma mycoides
Mycoplasma mycoides subsp. capri (Mmc) and subsp. mycoides (Mmm) are important ruminant pathogens worldwide causing diseases such as pleuropneumonia, mastitis and septicaemia. They express galactofuranose residues on their surface, but their role in pathogenesis has not yet been determined. The M...
Schieck, Elise G.
,
Lartigue, C.
,
Frey, J.
,
Vozza, N.
,
Hegermann, J.
,
Miller, R.A.
,
Valguarnera, E.
,
Muriuki, C.
,
Meens, J.
,
Nene, Vishvanath
,
Naessens, Jan
,
Weber, J.
,
Lowary, T.L.
,
Vashee, S.
,
Feldman, M.F.
,
Jores, Joerg
,
[Galactofuranose in Mycoplasma mycoides is important for membrane integrity and conceals adhesins but does not contribute to serum resistance]
,
Galactofuranose in Mycoplasma mycoides is important for membrane integrity and conceals adhesins but does not contribute to serum resistance
Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essent...
Jores, Joerg
,
Ma, L.
,
Ssajjakambwe, Paul
,
Schieck, Elise G.
,
Liljander, Anne M.
,
Chandran, S.
,
Stoffel, M.H.
,
Cippa, V.
,
Arfi, Y.
,
Assad-Garcia, N.
,
Falquet, L.
,
Sirand-Pugnet, P.
,
Blanchard, Alain
,
Lartigue, C.
,
Posthaus, H.
,
Labroussaa, F.
,
Vashee, S.
,
[Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain]
,
Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain
Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenesis. Th...
Lartigue, C.
,
Valverde Timana, Y.
,
Labroussaa, F.
,
Schieck, Elise G.
,
Liljander, Anne M.
,
Sacchini, Flavio
,
Posthaus, H.
,
Batailler, B.
,
Sirand-Pugnet, P.
,
Vashee, S.
,
Jores, Joerg
,
Blanchard, Alain
,
[Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches]
,
Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches
With the development of several new technologies using synthetic biology, it is possible to engineer genetically intractable organisms including Mycoplasma mycoides subspecies capri (Mmc), by cloning the intact bacterial genome in yeast, using the host yeast’s genetic tools to modify the cloned g...