Dromedaries in Africa and elsewhere carry the Middle East respiratory syndrome coronavirus (MERS-CoV). To search for evidence of autochthonous MERS-CoV infection in humans, we tested archived serum from livestock handlers in Kenya for MERS-CoV antibodies. Serologic evidence of infection was confi...
Liljander, Anne M.
,
Meyer, B.
,
Jores, Joerg
,
Müller, M.A.
,
Lattwein, E.
,
Njeru, I.
,
Bett, Bernard K.
,
Drosten, C.
,
Corman, V.M.
,
[MERS-CoV antibodies in humans, Africa, 2013–2014]
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MERS-CoV antibodies in humans, Africa, 2013–2014
Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae is a severe disease widespread in Africa and Asia. Limited knowledge is available on the pathogenesis of this organism, mainly due to the lack of a robust in vivo challenge model and the means to do ...
Liljander, Anne M.
,
Sacchini, F.
,
Stoffel, M.H.
,
Schieck, Elise G.
,
Stokar-Regenscheit, N.
,
Labroussaa, F.
,
Heller, M.
,
Salt, J.
,
Frey, J.
,
Falquet, L.
,
Goovaerts, D.
,
Jores, Joerg
,
[Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro]
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Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro
Jores, Joerg
,
Schieck, Elise G.
,
Liljander, Anne M.
,
Sacchini, Flavio
,
Posthaus, H.
,
Lartigue, C.
,
Blanchard, Alain
,
Labroussaa, F.
,
Vashee, S.
,
[In vivo role of capsular polysaccharide in Mycoplasma mycoides]
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In vivo role of capsular polysaccharide in Mycoplasma mycoides
Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides (Mmm) is a severe cattle disease, present in many countries in sub-Saharan Africa. The development of improved diagnostic tests and vaccines for CBPP control remains a research priority. Polyacrylamide gel ele...
Krasteva, I.
,
Liljander, Anne M.
,
Fischer, A.
,
Smith, D.G.E.
,
Inglis, N.F.
,
Scacchia, M.
,
Pini, A.
,
Jores, Joerg
,
Sacchini, F.
,
[Characterization of the in vitro core surface proteome of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious bovine pleuropneumonia]
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Characterization of the in vitro core surface proteome of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious bovine pleuropneumonia
Contagious caprine pleuropneumonia (CCPP) caused by Mycoplasma capricolum subsp. capripneumoniae is a severe epidemic affecting mainly domestic Caprinae species but also affects wild Caprinae species. M. capricolum subsp. capripneumoniae belongs to the “Mycoplasma mycoides cluster.” The disease f...
Contagious caprine pleuropneumonia (CCPP) is a highly contagious disease caused by Mycoplasma capricolum subsp. capripneumoniae that affects goats in Africa and Asia. Current available methods for the diagnosis of Mycoplasma infection, including cultivation, serological assays, and PCR, are time-...
Shiga toxin-producing Escherichia coli (STEC) cause gastrointestinal illnesses including non-bloody or bloody diarrhoea, haemorrhagic colitis (HC), and the haemolytic uremic syndrome (HUS). To investigate the occurrence of STEC among grazing dromedaries from Kenya, E. coli isolated from fecal mat...
Baschera, M.
,
Cernela, N.
,
Stevens, M.J.A.
,
Liljander, Anne M.
,
Jores, Joerg
,
Max Corman, V.
,
Nüesch-Inderbinen, M.
,
Stephan, R.
,
[Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels]
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Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels
Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essent...
Jores, Joerg
,
Ma, L.
,
Ssajjakambwe, Paul
,
Schieck, Elise G.
,
Liljander, Anne M.
,
Chandran, S.
,
Stoffel, M.H.
,
Cippa, V.
,
Arfi, Y.
,
Assad-Garcia, N.
,
Falquet, L.
,
Sirand-Pugnet, P.
,
Blanchard, Alain
,
Lartigue, C.
,
Posthaus, H.
,
Labroussaa, F.
,
Vashee, S.
,
[Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain]
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Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain
Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenesis. Th...
Lartigue, C.
,
Valverde Timana, Y.
,
Labroussaa, F.
,
Schieck, Elise G.
,
Liljander, Anne M.
,
Sacchini, Flavio
,
Posthaus, H.
,
Batailler, B.
,
Sirand-Pugnet, P.
,
Vashee, S.
,
Jores, Joerg
,
Blanchard, Alain
,
[Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches]
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Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches
Awino, Elias
,
Aye, R.
,
Bertrand, S.
,
Gesharisha, J.
,
Gicheru, N.
,
Jores, Joerg
,
Liljander, Anne M.
,
Muriuki, C.
,
Naessens, Jan
,
Nene, Vishvanath
,
Njoroge, T.
,
Nyongesa, S.
,
Pelle, Roger
,
Ssajjakambwe, P.
,
Saya, R.
,
Schieck, Elise G.
,
Steinaa, Lucilla
,
Svitek, Nicholas
,
Wasilwa, J.
,
[ILRI vaccine biosciences—Planting the orchard: (ILRI’s Vaccine Platform‐ILVAC)]
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ILRI vaccine biosciences—Planting the orchard: (ILRI’s Vaccine Platform‐ILVAC)