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Contagious caprine pleuropneumonia (CCPP) is a highly contagious disease caused by Mycoplasma capricolum subsp. capripneumoniae that affects goats in Africa and Asia. Current available methods for the diagnosis of Mycoplasma infection, including cultivation, serological assays, and PCR, are time-...


Liljander, Anne M.Mingyan YuO'Brien, E.Heller, M.Nepper, J.F.Weibel, D.B.Gluecks, Ilona V.Younan, M.Frey, J.Falquet, LaurentJores, Joerg[Field-applicable recombinase polymerase amplification assay for rapid detection of Mycoplasma capricolum subsp. Capripneumonia]Field-applicable recombinase polymerase amplification assay for rapid detection of Mycoplasma capricolum subsp. Capripneumonia

Shiga toxin-producing Escherichia coli (STEC) cause gastrointestinal illnesses including non-bloody or bloody diarrhoea, haemorrhagic colitis (HC), and the haemolytic uremic syndrome (HUS). To investigate the occurrence of STEC among grazing dromedaries from Kenya, E. coli isolated from fecal mat...


Baschera, M.Cernela, N.Stevens, M.J.A.Liljander, Anne M.Jores, JoergMax Corman, V.Nüesch-Inderbinen, M.Stephan, R.[Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels]Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essent...


Jores, JoergMa, L.Ssajjakambwe, PaulSchieck, Elise G.Liljander, Anne M.Chandran, S.Stoffel, M.H.Cippa, V.Arfi, Y.Assad-Garcia, N.Falquet, L.Sirand-Pugnet, P.Blanchard, AlainLartigue, C.Posthaus, H.Labroussaa, F.Vashee, S.[Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain]Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain

Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenesis. Th...


Lartigue, C.Valverde Timana, Y.Labroussaa, F.Schieck, Elise G.Liljander, Anne M.Sacchini, FlavioPosthaus, H.Batailler, B.Sirand-Pugnet, P.Vashee, S.Jores, JoergBlanchard, Alain[Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches]Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches

To analyze the distribution of Middle East respiratory syndrome coronavirus (MERS-CoV)–seropositive dromedary camels in eastern Africa, we tested 189 archived serum samples accumulated during the past 30 years. We identified MERS-CoV neutralizing antibodies in 81.0% of samples from the main camel...


Muller, M.A.Corman, V.M.Jores, JoergMeyer, B.Younan, M.Liljander, Anne M.Bosch, B.J.Lattwein, E.Hilali, M.Musa, B.E.Bornstein, S.Drosten, C.[MERS coronavirus neutralizing antibodies in camels, eastern Africa, 1983-1997]MERS coronavirus neutralizing antibodies in camels, eastern Africa, 1983-1997

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