Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single nucleotide polymorphisms (SNPs) of four major sheep breeds living at different altitudes in Nepal and downloaded SNP array data from addition...
Gorkhali, N.A.
,
Kunzhe Dong
,
Min Yang
,
Shen Song
,
Kader, A.
,
Shrestha, B.S.
,
Xiaohong He
,
Qian-Jun Zhao
,
Yabin Pu
,
Xiangchen Li
,
Kijas, J.
,
Weijun, Guan
,
Han Jianlin
,
Lin Jiang
,
Yuehui Ma
,
[Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas]
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Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas
Heteroplasmy due to length polymorphism with tandem repeats in mtDNAs within individual was hardly studied in domestic animals. In the present study, we identified intra-individual length variation in the control region of mtDNAs in Nepalese sheep by molecular cloning and sequencing techniques. W...
Gorkhali, N.A.
,
Lin Jiang
,
Shrestha, B.S.
,
Xiao-Hong He
,
Qian-Jun Zhao
,
Han Jianlin
,
Yue-Hui Ma
,
[High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep]
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High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep
MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle ti...
Qian-Jun Zhao
,
Ye Kang
,
Hong-Yang Wang
,
Weijun, Guan
,
Xiang-Chen Li
,
Lin Jiang
,
Xiao-Hong He
,
Yabin Pu
,
Han Jianlin
,
Yue-Hui Ma
,
Qian-Jun Zhao
,
[Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development]
,
Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development
Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel b...
Xuexue Liu
,
Yanli Zhang
,
Yefang Li
,
Jianfei Pan
,
Dandan Wang
,
Weihuang Chen
,
Zhuqing Zheng
,
Xiaohong He
,
Qianjun Zhao
,
Yabin Pu
,
Weijun Guan
,
Han Jianlin
,
Ludovic Orlando
,
Yuehui Ma
,
Lin Jiang
,
[EPAS1 gain-of-function mutation contributes to high altitude adaptation in Tibetan horses]
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EPAS1 gain-of-function mutation contributes to high altitude adaptation in Tibetan horses