The mechanisms whereby trypanotolerant N'Dama cattle control infection with Trypanosoma congolense are unknown. Previous studies have suggested that the monocytes of N'Dama cattle are more highly activated during infection than those of trypanosus ceptible Boan cattle. However, we have recently r...
Taylor, K.
,
Mertens, B.
,
Lutje, V.
,
Saya, R.
,
[Trypanosoma congolense infection of trypanotolerant N'Dama (Bos taurus) cattle is associated with decreased secretion of nitric oxide by interferon-gamma-activated monocytes and increased transcription of interleukin-10]
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Trypanosoma congolense infection of trypanotolerant N'Dama (Bos taurus) cattle is associated with decreased secretion of nitric oxide by interferon-gamma-activated monocytes and increased transcription of interleukin-10
Infection with African trypanosomes causes the diseases sleeping sickness in humans and nagana in cattle in sub-Saharan Africa. Suppression of cellular immune responses is a feature of trypanosomiasis in bovine, human, and murine hosts. Some aspects of immunosuppression in the murine model are me...
Taylor, K.
,
Lutje, V.
,
Mertens, B.
,
[Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression]
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Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression
Trypanosomiasis is a serious constraint to livestock production in sub-Saharan Africa. Some breeds of cattle are genetically more resistant to the pathogenic effects of trypanosome infection. We measured B-cell activation and the quantity and isotype of antibody produced at the cellular level in ...
Taylor, K.A.
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Lutje, V.
,
Kennedy, D.
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Authié, E.
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Boulange, A.F.
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Logan-Henfrey, L.L.
,
Gichuki, B.
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Gettinby, G.
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[Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle]
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Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle
A comparison of T-cell-mediated immune responses in trypanotolerant N'Dama and susceptible Boran cattle during primary infection with tsetse-transmitted Trypanosoma congolense was conducted to assess whether different patterns of T-cell activation occurred during trypanosome infection. Proliferat...
Lutje, V.
,
Taylor, K.A.
,
Kennedy, D.
,
Authié, E.
,
Boulange, A.F.
,
Gettinby, G.
,
[Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection]
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Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection
Analysis of serum antibody responses in cattle experimentally infected with Trypanosoma congolense suggested that antibody responses of trypanosusceptible Boran cattle are less efficient in isotype switching and affinity maturation than those of trypanotolerant N'Dama cattle. High levels of polys...