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A mathematical description of the transmission dynamics of the tick-borne infection Cowdria ruminantium in commercial beef enterprises in Zimbabwe was used to consider the potential impact of a candidate vaccine to prevent heartwater. The important characteristics of the vaccine were (1) a delay ...


O'Callaghan, C.J.Medley, G.F.Peter, T.F.Mahan, S.M.Perry, Brian D.[Predicting the effect of vaccination on the transmission dynamics of heartwater (Cowdria ruminantium infection)]Predicting the effect of vaccination on the transmission dynamics of heartwater (Cowdria ruminantium infection)

Heartwater, caused by the rickettsial organism Cowdria ruminantium, is a serious constraint to livestock development in much of sub-Saharan Africa. Traditionally, the disease has been controlled by the use of chemical acaricides to control the vector tick. The University of Florida/USAID-supporte...


Mukhebi, A.W.Chamboko, TafireyiO'Callaghan, C.J.Peter, T.F.Kruska, R.L.Medley, G.F.Mahan, S.M.Perry, Brian D.[An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe]An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe
Mahan, S.M.Hendershot, L.Black, S.J.[Control of trypanodestructive antibody responses and parasitemia in mice infected with Trypanosoma (Duttonella) vivax]Control of trypanodestructive antibody responses and parasitemia in mice infected with Trypanosoma (Duttonella) vivax

The authors highlight the reliance on repeated natural infections by tickborne pathogens to maintain immunity in immunized herds. That incidence of clinical heartwater in cattle, caused by Cowdria ruminantium, is low while intensive acaricide use interrupts transmission of pathogens. Evidence is ...


Perry, Brian D.Chamboko, TafireyiMahan, S.M.Medley, G.F.Minjauw, B.O'Callaghan, C.J.Peter, T.F.[The economics of integrated tick and tick-borne disease control on commercial farms in Zimbabwe]The economics of integrated tick and tick-borne disease control on commercial farms in Zimbabwe

Immune mechanisms against Cowdria ruminantium infection in livestock hosts are being investigated. This knowledge will be important for identification of protective antigens of C. ruminantium which will have application in the Development of vaccines against heartwater. T-cell Con-A supernatants ...


Mahan, S.M.Sileghem, M.R.Smith, G.Byrom, B.[Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract]Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract
Chamboko, TafireyiMukhebi, A.W.O'Callaghan, C.J.Peter, T.F.Kruska, R.L.Medley, G.F.Mahan, S.M.Perry, Brian D.[Economic impact of heartwater and its control in Zimbabwe]Economic impact of heartwater and its control in Zimbabwe
Minjauw, B.Perry, Brian D.Kruska, R.L.Peter, T.F.Mahan, S.M.Medley, G.F.O'Callaghan, C.J.[Economic impact assessment of heartwater in Southern Africa]Economic impact assessment of heartwater in Southern Africa

Heartwater is a tick-borne disease of cattle, sheep and goats and some wild ruminants prevalent in much of Africa and the Caribbean. It is caused by the rickettsial organism Cowdria ruminantium and transmitted by ticks of the genus Amblyomma. The disease has traditionally been controlled by the u...


Minjauw, B.Kruska, R.L.Odero, A.Randolph, Thomas F.McDermott, John J.Mahan, S.M.Perry, Brian D.[Economic impact assessment of Cowdria ruminantium infection and its control in Southern Africa]Economic impact assessment of Cowdria ruminantium infection and its control in Southern Africa
Mukhebi, A.W.Laker, C.D.Meltzer, M.I.Mahan, S.M.Perry, Brian D.[Assessing economics of alternative heartwater control strategies in Zimbabwe]Assessing economics of alternative heartwater control strategies in Zimbabwe

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