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Journal Article 2001

Autor: Peter, T.F. O'Callaghan, C.J. Medley, G.F. Perry, Brian D. Semu, S.M. Mahan, S.M.

The indirect MAP 1B ELISA based on the recombinant MAP 1B fragment of the immunodominant MAP 1 protein of Ehrlichia ruminantium is considered to be the most sensitive and specific assay for the serodiagnosis of heartwater. In this study, we evaluated its reliability in detecting exposure to E....

Enlace original: https://cgspace.cgiar.org/handle/10568/32906

Investigación en Agricultura
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Peter, T.F. ,  O'Callaghan, C.J. ,  Medley, G.F. ,  Perry, Brian D. ,  Semu, S.M. ,  Mahan, S.M. ,  [Population-based evaluation of the Ehrlichia ruminantium MAP 1B indirect ELISA] ,  Population-based evaluation of the Ehrlichia ruminantium MAP 1B indirect ELISA
Journal Article 1999

Autor: O'Callaghan, C.J. Medley, G.F. Peter, T.F. Mahan, S.M. Perry, Brian D.

A mathematical description of the transmission dynamics of the tick-borne infection Cowdria ruminantium in commercial beef enterprises in Zimbabwe was used to consider the potential impact of a candidate vaccine to prevent heartwater. The important characteristics of the vaccine were (1) a delay ...

Enlace original: https://cgspace.cgiar.org/handle/10568/33115

Investigación en Agricultura
Enlace permanente
O'Callaghan, C.J. ,  Medley, G.F. ,  Peter, T.F. ,  Mahan, S.M. ,  Perry, Brian D. ,  [Predicting the effect of vaccination on the transmission dynamics of heartwater (Cowdria ruminantium infection)] ,  Predicting the effect of vaccination on the transmission dynamics of heartwater (Cowdria ruminantium infection)
Journal Article 2002

Autor: Mwangi, D.M. McKeever, Declan J. Nyanjui, J.K. Barbet, A.F. Mahan, S.M.

There is growing evidence that immunity of cattle to Cowdria ruminantium infection is mediated by T lymphocytes. C. ruminantium antigens that stimulate these responses are therefore of considerable importance to the development of a sub-unit vaccine against the disease. We have examined T cell re...

Enlace original: https://cgspace.cgiar.org/handle/10568/33223

Investigación en Agricultura
Enlace permanente
Mwangi, D.M. ,  McKeever, Declan J. ,  Nyanjui, J.K. ,  Barbet, A.F. ,  Mahan, S.M. ,  [Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent] ,  Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent
Journal Article 1999

Autor: Chamboko, Tafireyi Mukhebi, A.W. Callaghan, C.J.O. Peter, T.F. Kruska, R.L. Medley, G.F. Mahan, S.M. Perry, Brian D.

As part of a series of studies associated with the development of improved vaccines for heartwater (a tick-borne disease of ruminant livestock caused by Cowdria ruminantium), field surveys were carried out to assess losses associated with the disease and the costs associated with controlling it i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33113

Investigación en Agricultura
Enlace permanente
Chamboko, Tafireyi ,  Mukhebi, A.W. ,  Callaghan, C.J.O. ,  Peter, T.F. ,  Kruska, R.L. ,  Medley, G.F. ,  Mahan, S.M. ,  Perry, Brian D. ,  [The control of heartwater on large-scale commercial and smallholder farms in Zimbabwe] ,  The control of heartwater on large-scale commercial and smallholder farms in Zimbabwe
Journal Article 1998

Autor: Mwangi, D.M. Mahan, S.M. Nyanjui, J.K. Taracha, E.L.N. McKeever, Declan J.

Peripheral blood mononuclear cells (PBMC) from immune cattle proliferate in the presence of autologous Cowdria ruminantium-infected endothelial cells and monocytes. Endothelial cells required treatment with T-cell growth factors to induce class II major histocompatibility complex expression prior...

Enlace original: https://cgspace.cgiar.org/handle/10568/28756

Investigación en Agricultura
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Mwangi, D.M. ,  Mahan, S.M. ,  Nyanjui, J.K. ,  Taracha, E.L.N. ,  McKeever, Declan J. ,  [Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes] ,  Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes
Journal Article 1998

Autor: Totte, P. McKeever, Declan J. Jongejan, F. Barbet, A. Mahan, S.M. Mwangi, D. Bensaid, A.

The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...

Enlace original: https://cgspace.cgiar.org/handle/10568/33077

Investigación en Agricultura
Enlace permanente
Totte, P. ,  McKeever, Declan J. ,  Jongejan, F. ,  Barbet, A. ,  Mahan, S.M. ,  Mwangi, D. ,  Bensaid, A. ,  [Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium] ,  Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium
Journal Article 1998

Autor: Mwangi, D.M. McKeever, Declan J. Nyanjui, J.K. Barbet, A.F. Mahan, S.M.

Heartwater (cowdriosis) is an infectious disease of domestic ruminants in Africa and the Carribean and is caused by a tick-borne intracellular rickettsial agent, Cowdria ruminantium. There is growing evidence that immunity of cattle to the disease is medicated by T. lymphocytes. Antigens that sti...

Enlace original: https://cgspace.cgiar.org/handle/10568/33078

Investigación en Agricultura
Enlace permanente
Mwangi, D.M. ,  McKeever, Declan J. ,  Nyanjui, J.K. ,  Barbet, A.F. ,  Mahan, S.M. ,  [Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle] ,  Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle

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