Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. Taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with...
Ballingall, K.T.
,
Waibochi, L.
,
Homes, E.C.
,
Woelk, C.H.
,
MacHugh, Niall D.
,
Lutje, V.
,
McKeever, Declan J.
,
[The CD45 locus in cattle: Allelic polymorphism and evidence for exceptional positive natural selection]
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The CD45 locus in cattle: Allelic polymorphism and evidence for exceptional positive natural selection
Understanding the basis of protective immunity to Cowdria ruminantium will facilitate the development of an effective subunit vaccine against heartwater in ruminants and contribute to a better definition of protective immune mechanisms to obligate intracellular pathogens in general. Until recentl...
Totte, P.
,
Bensaid, A.
,
Mahan, S.M.
,
Martínez, D.
,
McKeever, Declan J.
,
[Immune responses to Cowdria ruminantium infections]
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Immune responses to Cowdria ruminantium infections
We describe a highly sensitive, non-radioactive assay for T cell activation, based on the rapid induction of class II MHC expression by constitutively negative bovine endothelial cells, when cultured in the presence of supernatants derived from activated bovine T cells. We demonstrate the effecti...
Ballingall, K.T.
,
Mwangi, D.M.
,
MacHugh, Niall D.
,
Taracha, E.L.N.
,
Totte, P.
,
McKeever, Declan J.
,
[A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells]
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A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells
The p67 sporozoite antigen of Theileria parva has been fused to the C-terminal secretion signal of Escherichia coli hemolysin and expressed in secreted form by attenuated Salmonella dublin areA strain SL5631. The recombinant p67 antigen was detected in the supernatant of transformed bacterial cul...
Gentschev, I.
,
Glaser, I.
,
Goebel, W.
,
McKeever, Declan J.
,
Musoke, A.J.
,
Heussler, V.T.
,
[Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: Secretion of the product enhances specific antibody responses in cattle]
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Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: Secretion of the product enhances specific antibody responses in cattle