T cells bearing the gamma delta antigen receptor (gamma delta T cells) can constitute up to 50 percent of T cells in the peripheral blood and lymphoid organs of young cattle. We present data showing that gamma delta T cells are involved in immune responses against Theileria parva. Gamma delta T c...
Daubenberger, C.A.
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Taracha, E.L.N.
,
Gaidulis, L.
,
Davis, W.C.
,
McKeever, Declan J.
,
[Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva]
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Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva
Morrison, W. Ivan
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MacHugh, Niall D.
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Bensaid, A.M.
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Goddeeris, B.M.
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Teale, A.J.
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McKeever, Declan J.
,
[A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers]
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A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers
The protozoan parasite Theileria parva infects and transforms bovine lymphocytes, giving rise to a fatal lympho-proliferative condition known as East Coast fever. Although immune cattle mount strong cytolytic T. lymphocyte responses to the parasite, naive animals appear unable to respond and deve...
McKeever, Declan J.
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Nyanjui, J.K.
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Ballingall, K.T.
,
[In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages]
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In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages
There is growing evidence that immunity of cattle to Cowdria ruminantium infection is mediated by T lymphocytes. C. ruminantium antigens that stimulate these responses are therefore of considerable importance to the development of a sub-unit vaccine against the disease. We have examined T cell re...
Mwangi, D.M.
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McKeever, Declan J.
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Nyanjui, J.K.
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Barbet, A.F.
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Mahan, S.M.
,
[Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent]
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Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent
Theileria parva is the causal agent of East Coast fever (ECF), a fatal disease of cattle characterized by pyrexia, transient lymphadenopathy and panleukopenia. We have evaluated monoclonal antibodies (mAb) against three distinct antigens (p67, PIM and p32) of the parasite as immunohistological re...
Honda, Y.
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Matsubara, Y.
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Morzaria, S.P.
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McKeever, Declan J.
,
[Immunohistochemical detection of parasite antigens in Theileria parva-infected bovine lymphocytes]
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Immunohistochemical detection of parasite antigens in Theileria parva-infected bovine lymphocytes
Shaw, M.K.
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Tilney, L.G.
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McKeever, Declan J.
,
[Tick salivary gland extract an interleukin-2 stimulation enhance susceptibility of lymphocytes to infection by Theileria parva sporozoites]
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Tick salivary gland extract an interleukin-2 stimulation enhance susceptibility of lymphocytes to infection by Theileria parva sporozoites
Peripheral blood mononuclear cells (PBMC) from immune cattle proliferate in the presence of autologous Cowdria ruminantium-infected endothelial cells and monocytes. Endothelial cells required treatment with T-cell growth factors to induce class II major histocompatibility complex expression prior...
Mwangi, D.M.
,
Mahan, S.M.
,
Nyanjui, J.K.
,
Taracha, E.L.N.
,
McKeever, Declan J.
,
[Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes]
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Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes
Howard, C.J.
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Sopp, P.
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Parsons, K.R.
,
McKeever, Declan J.
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Taracha, E.L.N.
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Jones, B.V.
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MacHugh, Niall D.
,
Morrison, W. Ivan
,
[Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45]
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Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45
McKeever, Declan J.
,
Awino, J.
,
Morrison, W. Ivan
,
[Afferent lymph veiled cells prime CD4+ T cell responses in vivo]
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Afferent lymph veiled cells prime CD4+ T cell responses in vivo