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Journal Article 2002

Autor: Mwangi, D.M. McKeever, Declan J. Nyanjui, J.K. Barbet, A.F. Mahan, S.M.

There is growing evidence that immunity of cattle to Cowdria ruminantium infection is mediated by T lymphocytes. C. ruminantium antigens that stimulate these responses are therefore of considerable importance to the development of a sub-unit vaccine against the disease. We have examined T cell re...

Enlace original: https://cgspace.cgiar.org/handle/10568/33223

Investigación en Agricultura
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Mwangi, D.M. ,  McKeever, Declan J. ,  Nyanjui, J.K. ,  Barbet, A.F. ,  Mahan, S.M. ,  [Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent] ,  Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent
Journal Article 1999

Autor: Totte, P. Bensaid, A. Mahan, S.M. Martínez, D. McKeever, Declan J.

Understanding the basis of protective immunity to Cowdria ruminantium will facilitate the development of an effective subunit vaccine against heartwater in ruminants and contribute to a better definition of protective immune mechanisms to obligate intracellular pathogens in general. Until recentl...

Enlace original: https://cgspace.cgiar.org/handle/10568/33105

Investigación en Agricultura
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Totte, P. ,  Bensaid, A. ,  Mahan, S.M. ,  Martínez, D. ,  McKeever, Declan J. ,  [Immune responses to Cowdria ruminantium infections] ,  Immune responses to Cowdria ruminantium infections
Journal Article 1998

Autor: Mwangi, D.M. Mahan, S.M. Nyanjui, J.K. Taracha, E.L.N. McKeever, Declan J.

Peripheral blood mononuclear cells (PBMC) from immune cattle proliferate in the presence of autologous Cowdria ruminantium-infected endothelial cells and monocytes. Endothelial cells required treatment with T-cell growth factors to induce class II major histocompatibility complex expression prior...

Enlace original: https://cgspace.cgiar.org/handle/10568/28756

Investigación en Agricultura
Enlace permanente
Mwangi, D.M. ,  Mahan, S.M. ,  Nyanjui, J.K. ,  Taracha, E.L.N. ,  McKeever, Declan J. ,  [Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes] ,  Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes
Journal Article 1999

Autor: Totte, P. Nyanjui, J. Bensaid, A. McKeever, Declan J.

Cowdria-specific CD4<sup(+)> T-cell lines generated from immunized cattle responded to both soluble and membrane proteins of the agent. The lines produced the Cowdria-inhibitory cytokine IFN-<gamma> in response to soluble antigens fractionated by gel filtration and fast performance liquid chromat...

Enlace original: https://cgspace.cgiar.org/handle/10568/29866

Investigación en Agricultura
Enlace permanente
Totte, P. ,  Nyanjui, J. ,  Bensaid, A. ,  McKeever, Declan J. ,  [Bovine CD4<sup(+)> T-cell lines reactive with soluble and membrane antigens of Cowdria ruminantium] ,  Bovine CD4<sup(+)> T-cell lines reactive with soluble and membrane antigens of Cowdria ruminantium
Journal Article 1997

Autor: Totte, P. McKeever, Declan J. Martínez, D. Bensaid, A.

Cattle were successfully immunized against heartwater with a lysate of Cowdria ruminantium formulated in Freund's adjuvant. Vaccinated animals proved fully resistant to virulent challenge 3 and 10 months after vaccination. For the first time a helper T lymphocyte response to Cowdria antigens was ...

Enlace original: https://cgspace.cgiar.org/handle/10568/28765

Investigación en Agricultura
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Totte, P. ,  McKeever, Declan J. ,  Martínez, D. ,  Bensaid, A. ,  [Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium] ,  Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium
Journal Article 1998

Autor: Totte, P. McKeever, Declan J. Jongejan, F. Barbet, A. Mahan, S.M. Mwangi, D. Bensaid, A.

The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...

Enlace original: https://cgspace.cgiar.org/handle/10568/33077

Investigación en Agricultura
Enlace permanente
Totte, P. ,  McKeever, Declan J. ,  Jongejan, F. ,  Barbet, A. ,  Mahan, S.M. ,  Mwangi, D. ,  Bensaid, A. ,  [Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium] ,  Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium
Journal Article 1998

Autor: Mwangi, D.M. McKeever, Declan J. Nyanjui, J.K. Barbet, A.F. Mahan, S.M.

Heartwater (cowdriosis) is an infectious disease of domestic ruminants in Africa and the Carribean and is caused by a tick-borne intracellular rickettsial agent, Cowdria ruminantium. There is growing evidence that immunity of cattle to the disease is medicated by T. lymphocytes. Antigens that sti...

Enlace original: https://cgspace.cgiar.org/handle/10568/33078

Investigación en Agricultura
Enlace permanente
Mwangi, D.M. ,  McKeever, Declan J. ,  Nyanjui, J.K. ,  Barbet, A.F. ,  Mahan, S.M. ,  [Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle] ,  Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle

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