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Morrison, W. IvanMacHugh, Niall D.Bensaid, A.M.Goddeeris, B.M.Teale, A.J.McKeever, Declan J.[A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers]A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers

Cattle that recover from Theileria parva infection are solidly immune to rechallenge with homologous parasites. Most of the ILRAD/ILRI immunological research into the disease has focused on defining the basis of this protection. Over 15 years of basic and applied immunological research at ILRAD/I...


McKeever, Declan J.[Multi-component subunit vaccines against Theileria parva]Multi-component subunit vaccines against Theileria parva

ILRAD outlined two different areas of research concern to the trypanosomiasis program. One goal was to identify trypanosomal antigens responsible for the immunopathogenesis of the disease by determining how the infection of cattle with trypanosomes affects their immune system. A second goal was...


McKeever, Declan J.Sileghem, M.R.Gardiner, Peter R.Gaidulis, L.[Summary of discussion]Summary of discussion
Grace, DeliaJones, B.McKeever, Declan J.Pfeiffer, Dirk U.Mutua, F.Njuki, JemimahMcDermott, John J.Rushton, JonathanSaid, Mohammed YahyaKock, R.Alonso, Silvia[A systematic review of zoonoses at the interface of livestock and wildlife]A systematic review of zoonoses at the interface of livestock and wildlife
McKeever, Declan J.[Progress towards a vaccine against Theileria parva: Relevance for heartwater research]Progress towards a vaccine against Theileria parva: Relevance for heartwater research

Theileria parva, an obligate intracellular protozoan parasite of cattle, causes East Coast fever, a fatal, lymphoproliferative disease, endemic in large areas of East and Central Africa. The mammalian-infective sporozoites of T. parva mature within the salivary glands of the ixodid tick Rhipiceph...


Wells, C.W.Awino, EliasMcKeever, Declan J.[Theileria parva sporozoite invasion and development within bovine dendritic cells]Theileria parva sporozoite invasion and development within bovine dendritic cells

A study was undertaken to compare the absorption and distribution of the antitrypanosomal drug diminazene aceturate in plasma, cerebrospinal fluid (CSF) and lymph of goats. The study comprised three groups of three goats each. Animals in each group were treated with a single intramuscular dose of...


Mamman, M.McKeever, Declan J.Peregrine, A.S.[Comparative pharmacokinetics of diminazene in plasma, cerebrospinal fluid and lymph of goats]Comparative pharmacokinetics of diminazene in plasma, cerebrospinal fluid and lymph of goats
Nene, VishvanathBishop, Richard P.Dolan, T.T.McKeever, Declan J.Ole-MoiYoi, O.K.Morzaria, S.P.Musoke, A.J.Shaw, M.K.Toye, Philip G.Young, A.S.[Theileria parva: current status]Theileria parva: current status

This paper determines whether contact between parasite-specific CD4+ T cells and CD8+ T cells is an essential requirement for helper function, additional experiments were performed using two-chamber culture plates incorporating semi-porous membranes. TpM were co-cultured with naive or immune CD8 ...


Taracha, E.L.N.McKeever, Declan J.[Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes]Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes

Theileria parva, a protozoan parasite of cattle, causes a disease called East Coast fever. The disease is of economic importance because it causes high morbidity and mortality and limits the development of the cattle industry. This paper highlights the experiences with immunization against Theile...


Musoke, A.J.McKeever, Declan J.Morzaria, S.P.Nkonge, C.Nene, Vishvanath[Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen]Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen

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