Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has historically been attributed to pulmonary infiltration by infected lymphocytes. However, immunohistochemical staining of tissue from T. parva inf...
Fry, Lindsay M.
,
Schneider, D.A.
,
Frevert, C.W.
,
Nelson, D.D.
,
Morrison, W. Ivan
,
Knowles, Donald P.
,
[East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure]
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East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure
Integrative management of wildlife and livestock requires a clear understanding of the diseases transmitted between the two populations. The tick-borne protozoan parasite Theileria parva causes two distinct diseases in cattle, East Coast fever and Corridor disease, following infection with parasi...
Sitt, T.
,
Poole, Elizabeth J.
,
Ndambuki, Gideon M.
,
Mwaura, S.
,
Njoroge, T.
,
Omondi, G.P.
,
Mutinda, M.
,
Mathenge, J.
,
Prettejohn, G.
,
Morrison, W. Ivan
,
Toye, Philip G.
,
[Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva]
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Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva
Sitt, T.
,
Pelle, Roger
,
Chepkwony, M.C.
,
Morrison, W. Ivan
,
Toye, Philip G.
,
[Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines]
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Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines
An infection and treatment protocol involving infection with a mixture of three parasite isolates and simultaneous treatment with oxytetracycline is currently used to vaccinate cattle against Theileria parva. While vaccination results in high levels of protection in some regions, little or no pro...
Hemmink, J.D.
,
Sitt, T.
,
Pelle, Roger
,
Klerk-Lorist, L.M. de
,
Shiels, B.
,
Toye, Philip G.
,
Morrison, W. Ivan
,
Weir, W.
,
[Ancient diversity and geographical sub-structuring in African buffalo Theileria parva populations revealed through metagenetic analysis of antigen-encoding loci]
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Ancient diversity and geographical sub-structuring in African buffalo Theileria parva populations revealed through metagenetic analysis of antigen-encoding loci