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Young, A.S.Ochanda, H.Perry, Brian D.Morzaria, S.P.Dolan, T.T.Medley, G.F.Gettinby, G.[The biology of the transmission dynamics of Theileria parva]The biology of the transmission dynamics of Theileria parva
O'Callaghan, C.J.Medley, G.F.Kiara, Henry K.McDermott, John J.Musoke, A.J.Morzaria, S.P.Perry, Brian D.[Quantitative analysis of dose-response effects in the transmission dynamics of Theileria parva and the impact of sporozoite-neutralising vaccines]Quantitative analysis of dose-response effects in the transmission dynamics of Theileria parva and the impact of sporozoite-neutralising vaccines
Bishop, Richard P.Musoke, A.J.Skilton, Robert A.Morzaria, S.P.Gardner, M.Nene, Vishvanath[Theileria: Life cycle stages associated with the ixodid tick vector]Theileria: Life cycle stages associated with the ixodid tick vector

Polymorphic, multicopy gene families are frequently located in subtelomeric regions of the genomes of parasitic protozoa. Theileria parva telomere-associated (TA) DNA from two chromosomes contained long open reading frames (ORFs) 54% identical at the N-termini whose ends were 2670 and 2680 bp fro...


Bishop, Richard P.Gobright, E.I.Nene, VishvanathMorzaria, S.P.Musoke, A.J.Sohanpal, B.K.[Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres]Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres

Theileria are economically important, intra-cellular protozoa, transmitted by ixodid ticks, which infect wild and domestic ruminants. In the mammalian host, parasites infect leukocytes and erythrocytes. In the arthropod vector they develop in gut epithelial cells and salivary glands. All four int...


Bishop, Richard P.Musoke, A.J.Morzaria, S.P.Gardner, M.Nene, Vishvanath[Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks]Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks
Morzaria, S.P.Katende, J.M.Kairo, A.Nene, VishvanathMusoke, A.J.[New methods for the diagnosis of Babesia bigemina infection]New methods for the diagnosis of Babesia bigemina infection

When compared with other Apicomplexan organisms. Theileria parva has an execptionally small, 10-12 Mbp. genome. There are only 4 chromosomes, each in the Mbp range, and a complete physical map, based on SfiI linking data, is available for each one. A number of genes and cDNAs have been mapped to ...


Nene, VishvanathMorzaria, S.P.Bishop, Richard P.[Organisation and informational content of the Theileria parva genome]Organisation and informational content of the Theileria parva genome

Theileria are tick-transmitted, haemoprotozoan parasites infecting wild and domestic ungulates throughout many areas of the world. The most economically important species are T. parva and T. annulata which are pathogenic to cattle, and T. lestoquardi (syn hirci) which is pathogenic to sheep and g...


Skilton, Robert A.Musoke, A.J.Nene, VishvanathWasawo, D.P.S.Wells, C.W.Spooner, P.R.Bishop, Richard P.Osaso, J.Nkonge, C.Latif, A.Morzaria, S.P.[Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen]Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen

Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These anti...


Hall, R.Boulter, N.R.Brown, C.G.D.Wilkie, G.Kirvar, E.Nene, VishvanathMusoke, A.J.Glass, E.J.Morzaria, S.P.[Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva]Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva

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