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The review discusses the roles of serum xanthine oxidise serum catalase and trypanosome-specific immune responses in the regulation of the level of trypanosome parasitaemic waves in Cape buffalo. Topics of discussion include non-specific trypanocidal activity in cape buffalo serum; recurrence of ...


Black, S.J.Sicard, E.L.Murphy, N.Nolan, D.[Innate and acquired control of trypanosome parasitaemia in Cape buffalo]Innate and acquired control of trypanosome parasitaemia in Cape buffalo

Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...


Kitani, H.Black, S.J.Nakamura, Y.Naessens, JanMurphy, N.Yokomizo, Y.Gibson, John P.Iraqi, F.A.[Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures]Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures

Clearance of trypanosomes from the blood of infected Cape buffalo was associated with the development of two responses: (i) complement-dependent and clone-specific lytic activity and (ii) complement-independent trypanocidal activity that was not restricted by trypanosome clone or species. This la...


Wang, Q.Murphy, N.Black, S.J.[Infection-associated decline of Cape buffalo blood catalase augments serum srypanocidal activity]Infection-associated decline of Cape buffalo blood catalase augments serum srypanocidal activity

In higher eukaryotes, key steps in the control of growth and proliferation are regulated by protein phosphorylation. However, little is known abot the role of protein phosphorylation in the development cycles of pathogenic protozoa. In Trypanosoma brucei, only the bloodform and procyclic form sta...


Parsons, M.Carter, V.Muthiani, A.Murphy, N.[Trypanosoma congolense: Developmental regulation of protein kinases and tyrosine phosphorylation during the life cycle]Trypanosoma congolense: Developmental regulation of protein kinases and tyrosine phosphorylation during the life cycle
Alsford, S.Ersfeld, K.Murphy, N.Gull, K.[Characterisation of a repetitive genomic sequence of Trypanosoma brucei and its nuclear localisation during interphase and mitosis]Characterisation of a repetitive genomic sequence of Trypanosoma brucei and its nuclear localisation during interphase and mitosis

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