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The review discusses the current field status of human and bovine trypanosomiases, and focuses on the molecular basis of innate and acquired control of African trypanosomes in people, cattle and Cape buffalo


Black, S.J.Seed, J.R.Murphy, N.B.[Innate and acquired resistance to African trypanosomiasis]Innate and acquired resistance to African trypanosomiasis

Nuclear extrachromosomal DNA elements have been identified in several kinetoplastids such as Leishmania and Trypanosoma cruzi, but never in Trypanosoma brucei. They can occur naturally or arise spontaneously as the result of sublethal drug exposure of parasites. In most cases, they are represente...


Alsford, N.S.Navarro, M.Jamnadass, Ramni H.Dunbar, H.Ackroyd, M.Murphy, N.B.Gull, K.Ersfeld, K.[The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei]The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei

Peregrine, A.S.Sutherland, I.A.Mutharia, L.Jamnadass, Ramni H.Gray, M.A.Codjia, V.Aliu, Y.O.Mamman, M.Silayo, R.D'Ieteren, G.D.M.Moloo, S.K.Murphy, N.B.[Overview of the chemotherapy research program at ILRAD]Overview of the chemotherapy research program at ILRAD
Dirie, M.F.Murphy, N.B.Gardiner, Peter R.[DNA fingerprinting of Trypanosoma vivax isolates rapidly identifies intraspecific relationships]DNA fingerprinting of Trypanosoma vivax isolates rapidly identifies intraspecific relationships
Pelle, RogerChepkorir, N.Pandit, P.Murphy, N.B.[RADES-PCR rapidly identifies differentially expressed trypanosome sequences both in vitro and in vivo]RADES-PCR rapidly identifies differentially expressed trypanosome sequences both in vitro and in vivo

Studies on infections with drug-resistant trypanosomes indicate that the majority of parasites in a population are sensitive to the drug dose used to select the population (Mamman et al., 1993). This study was initiated to examine whether a drug-resistant trypanosome population could influence th...


Burudi, E.M.E.Peregrine, A.S.Majiwa, P.A.O.Murphy, N.B.[Evaluation of response to treatment of mixed trypanosome infection in goats using the polymerase chain reaction]Evaluation of response to treatment of mixed trypanosome infection in goats using the polymerase chain reaction

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