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A Trypanosoma brucei brucei DNA repeat sequence termed NlaIII repeat (NR) was originally isolated from a multidrug-resistant field isolate CP547 [Jamnadass, R., 1995. Identification and characterisation of an extrachromosomal element from a multidrug-resistant isolate of T. brucei brucei, Ph.D. t...


Jamnadass, Ramni H.Pelle, RogerPandit, P.Ricard, B.Murphy, N.B.[Trypanosoma brucei: Composition, organisation, plasticity, and differential transcription of NlaIII repeat elements in drug-resistant and sensitive isolates]Trypanosoma brucei: Composition, organisation, plasticity, and differential transcription of NlaIII repeat elements in drug-resistant and sensitive isolates
Pelle, RogerMurphy, N.B.[Stage-specific differential polyadenylation of mini-exon derived RNA in African trypanosomes]Stage-specific differential polyadenylation of mini-exon derived RNA in African trypanosomes

Experiments were carried out in goats to determine the frequency with which diminazene-resistant trypanosomes occur in parasite populations before and after the intramuscular treatment of the goats with diminazene aceturate. Trypanosoma congolense IL3274, a diminazene-resistant clone, was used to...


Mamman, M.Williams, D.J.L.Murphy, N.B.Peregrine, A.S.[Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense]Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense
Murphy, N.B.Pelle, Roger[The use of arbitrary primers and the RADES method for the rapid identification of developmentally regulated genes in trypanosomes]The use of arbitrary primers and the RADES method for the rapid identification of developmentally regulated genes in trypanosomes
Pelle, RogerMcOdimba, F.A.Chuma, FrancisWasawo, D.Pearson, T.W.Murphy, N.B.[The African trypanosome cyclophilin A homologue contains unusual conserved central and N-terminal domains and is developmentally regulated]The African trypanosome cyclophilin A homologue contains unusual conserved central and N-terminal domains and is developmentally regulated

The review discusses the current field status of human and bovine trypanosomiases, and focuses on the molecular basis of innate and acquired control of African trypanosomes in people, cattle and Cape buffalo


Black, S.J.Seed, J.R.Murphy, N.B.[Innate and acquired resistance to African trypanosomiasis]Innate and acquired resistance to African trypanosomiasis

The frequency of trypanosomes resistant to diminazene aceturate at a dose of 26 mg/kg of bwt was investigated for populations of Trypanosoma congolense IL 3274 which reappeared in infected mice after intraperitoneal treatment with diminazene aceturate at the same dosage. At inoculum sizes of 102,...


Mamman, M.Gettinby, N.B.Murphy, N.B.Kemei, S.Peregrine, A.S.[Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate]Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate

The QM protein has been reported to have roles in both tumour suppression and transcription factor regulation in vertebrate cells, and in ribosome stability in both yeast and mammals. The present study isolated the QM gene of Trypanosoma brucei and determined its sequence. Alignment with QM seque...


Lillico, S.G.Mottram, J.C.Murphy, N.B.Welburn, S.C.[Characterisation of the QM gene of Trypanosoma brucei]Characterisation of the QM gene of Trypanosoma brucei
Peregrine, A.S.Knowles, G.Ibitayo, A.I.Scott, J.R.Moloo, S.K.Murphy, N.B.[Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense]Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense

Nuclear extrachromosomal DNA elements have been identified in several kinetoplastids such as Leishmania and Trypanosoma cruzi, but never in Trypanosoma brucei. They can occur naturally or arise spontaneously as the result of sublethal drug exposure of parasites. In most cases, they are represente...


Alsford, N.S.Navarro, M.Jamnadass, Ramni H.Dunbar, H.Ackroyd, M.Murphy, N.B.Gull, K.Ersfeld, K.[The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei]The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei

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