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Rovis, L.Musoke, A.J.Moloo, S.K.[Failure of trypanosomal membrane antigens to induce protection against tsetse-transmitted Trypanosoma vivax or Trypanosoma brucei in goats and rabbits]Failure of trypanosomal membrane antigens to induce protection against tsetse-transmitted Trypanosoma vivax or Trypanosoma brucei in goats and rabbits
Nantulya, V.M.Musoke, A.J.Moloo, S.K.Ngaira, J.M.[Analysis of the variable antigen composition of Trypanosoma brucei metacyclic trypanosomes using monoclonal antibodies]Analysis of the variable antigen composition of Trypanosoma brucei metacyclic trypanosomes using monoclonal antibodies

The transcriptional control of gene expression is not well documented in the Arthropoda. We describe transcriptional analysis of two exceptionally divergent homologues (Ra86) of the Bm86 gut antigen from Rhipicephalus appendiculatus. Bm86 forms the basis of a commercial vaccine for the control of...


Kamau, L.Skilton, Robert A.Odongo, David O.Mwaura, S.Githaka, Naftaly W.Kanduma, E.G.Obura, M.Kabiru, E.Orago, A.Musoke, A.J.Bishop, Richard P.[Differential transcription of two highly divergent gut-expressed Bm86 antigen gene homologues in the tick Rhipicephalus appendiculatus (Acari: Ixodida)]Differential transcription of two highly divergent gut-expressed Bm86 antigen gene homologues in the tick Rhipicephalus appendiculatus (Acari: Ixodida)
Shompole, S.McElwain, T.F.Jasmer, D.P.Hines, S.A.Katende, J.Musoke, A.J.Rurangirwa, F.R.McGuire, T.C.[Identification of Babesia bigemina infected erythrocyte surface antigens containing epitopes conserved among strains]Identification of Babesia bigemina infected erythrocyte surface antigens containing epitopes conserved among strains
Musoke, A.J.Barbet, F.[Activation of complement by variant-specific surface antigen of Trypanosoma brucei]Activation of complement by variant-specific surface antigen of Trypanosoma brucei

Tick-borne diseases (TBDs) are a major economic constraint to livestock production in sub-Saharan Africa. ILRI is focussing on developing a range of products, such as vaccines, diagnostics and decision support services to underpin improved control programmes against these diseases. We have develo...


Morzaria, S.P.Katende, J.Musoke, A.J.Nene, VishvanathSkilton, Robert A.Bishop, Richard P.[Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa]Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa

Current serological tests for Babesia bigemina use semipurified merozoite antigens derived from infected erythrocytes. One of the major drawbacks of these tests is that antigen quality can vary from batch to batch. Since the quality of the antigen contributes to the sensitivity and specificity of...


Tebele, N.Skilton, Robert A.Katende, J.Wells, C.W.Nene, VishvanathMcElwain, T.F.Morzaria, S.P.Musoke, A.J.[Cloning, characterization and expression of a 200 Kilodalton diagnostic antigen of Babesia bigemina]Cloning, characterization and expression of a 200 Kilodalton diagnostic antigen of Babesia bigemina
Barbet, A.F.Musoke, A.J.Shapiro, S.Z.Mpimbaza, G.W.N.McGuire, T.C.[Identification of the fragment containing cross-reacting antigenic determinants of the variable surface glycoprotein of Trypanosoma brucei]Identification of the fragment containing cross-reacting antigenic determinants of the variable surface glycoprotein of Trypanosoma brucei

To evaluate vaccinia virus as a delivery system for recombinant antigen in cattle, calves were immunized with a recombinant vaccinia virus (rVV) expressing the sporozoite surface antigen (p67) of Theileria parva (V-67) combined with those expressing bovine IL-4 (V-IL4) or IL-2 (V-IL2). The anti-p...


Honda, Y.Waithaka, M.M.Taracha, E.L.N.Duchateau, L.Musoke, A.J.McKeever, Declan J.[Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection]Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection
Barbet, A.F.Musoke, A.J.Mpimbaza, G.W.N.Rovis, L.[Isolation of a variant antigen fragment containing cross-reacting determinants from Trypanosoma brucei]Isolation of a variant antigen fragment containing cross-reacting determinants from Trypanosoma brucei

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