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African buffalo (Syncerus caffer) and trypanotolerant N'Dama cattle were compared for their resistance to overcome Trypanosoma congolense and T. vivax infections. Several compartments from the immune system were followed during the infections and compared between the two species. Several parmaete...


Olubayo, R.O.Moloo, S.K.Naessens, Jan[Comparative parasite development in African buffalo and N'Dama cattle infected with either Trypanosoma congolense or T. vivax]Comparative parasite development in African buffalo and N'Dama cattle infected with either Trypanosoma congolense or T. vivax
Fritsch, G.Nelson, R.T.Muiya, P.Naessens, JanBlack, S.J.[Characterization of bovine haemopoietic progenitor cells using monoclonal antibodies and fluorocytometry]Characterization of bovine haemopoietic progenitor cells using monoclonal antibodies and fluorocytometry
Howard, C.J.Morrison, W. IvanBrown, W.C.Naessens, JanSopp, P.[Demonstration of two allelic forms of the bovine T cell antigen Bo5 (CD5) and studies of their inheritance]Demonstration of two allelic forms of the bovine T cell antigen Bo5 (CD5) and studies of their inheritance

West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitaem...


Naessens, JanLeak, S.G.A.Kennedy, D.J.Kemp, Stephen J.Teale, A.J.[Responses of bovine chimaeras combining trypanosomiasis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]Responses of bovine chimaeras combining trypanosomiasis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense

Murine models have suggested that CD8 T cells might play a major parasite-promoting role in African trypanosomiasis. To assess the role of these cells in a natural host environment, we have depleted CD8 cells from Boran cattle in vivo and subsequently infected these animals with Trypanosoma congo...


Sileghem, M.R.Naessens, Jan[Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?]Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?

Two populations of B lymphocytes. B-1 (CD5- and or CD1 lb-) and B-2 (CD5- and CD1 lb-) cells have been described. In mice, which is the species of reference for B-1 and B-2 cell studies, these two subsets present different developmental schemes, phenotypes, antibody repertoires, localization and ...


Chevallier, N.Berthelemy, M.Laine, V.Rhun, D. leFemenia, F.Polack, B.Naessens, JanLevy, D.Schwartz-Cornil, I.[B-1-like cells exist in sheep. Characterization of their phenotype and behaviour]B-1-like cells exist in sheep. Characterization of their phenotype and behaviour

Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...


Kitani, H.Black, S.J.Nakamura, Y.Naessens, JanMurphy, N.Yokomizo, Y.Gibson, John P.Iraqi, F.A.[Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures]Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures

Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differenc...


Naessens, JanTeale, A.J.Sileghem, M.R.[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]Identification of mechanisms of natural resistance to African trypanosomiasis in cattle

It is known that different breeds of cattle display differential susceptibilities to Trypanosome congolense infections, and that N'Dama cattle remain more productive after infection than Boran cattle which are more susceptible to T. congolense. Macrophages from both breeds were cultured in vitro ...


Kazuhiro, Y.Agaba, MorrisIraqi, F.A.Naessens, Jan[Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense]Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense

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