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Microarrays are an important and widely used tool. Applications include capturing genomic DNA for high-throughput sequencing in addition to the traditional monitoring of gene expression and identifying DNA copy number variations. Sequence mismatches between probe and target strands are known to a...


Rennie, C.Noyes, H.A.Kemp, Stephen J.Hulme, H.Brass, A.Hoyle, D.C.[Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays]Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays

Differences in gene expression may be caused by nearby DNA polymorphisms (cis regulation) or by interactions of gene control regions with polymorphic transcription factors (trans regulation). Trans acting loci are much harder to detect than cis acting loci and their effects are much more sensitiv...


Noyes, H.A.Agaba, MorrisAnderson, S.Archibald, A.L.Brass, A.Gibson, John P.Hall, L.Hulme, H.Oh, S.J.Kemp, Stephen J.[Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background]Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background

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