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Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development ...


Graham, S.P.Honda, Y.Pelle, RogerMwangi, D.M.Glew, E.J.Villiers, Etienne P. deShah, TushaarBishop, Richard P.Bruggen, P. van derNene, VishvanathTaracha, E.L.N.[A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology]A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology

Awino, EliasAye, R.Bertrand, S.Gesharisha, J.Gicheru, N.Jores, JoergLiljander, Anne M.Muriuki, C.Naessens, JanNene, VishvanathNjoroge, T.Nyongesa, S.Pelle, RogerSsajjakambwe, P.Saya, R.Schieck, Elise G.Steinaa, LucillaSvitek, NicholasWasilwa, J.[ILRI vaccine biosciences—Planting the orchard: (ILRI’s Vaccine Platform‐ILVAC)]ILRI vaccine biosciences—Planting the orchard: (ILRI’s Vaccine Platform‐ILVAC)

Theileria parva antigens recognized by cytotoxic T lymphocytes (CTLs) are prime vaccine candidates against East Coast Fever in cattle. A strategy for enhancing induction of parasite-specific T cell responses by increasing recruitment and activation of dendritic cells (DCs) at the immunization sit...


Mwangi, D.M.Honda, Y.Graham, S.P.Pelle, RogerTaracha, E.L.N.Gachanja, J.Nyanjui, J.K.Bray, J.Palmer, G.H.Brown, W.C.Mwangi, W.[Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses]Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses
Mpenda, F.N.Tiambo, Christian K.Kyallo, MartinaPelle, RogerLyantagaye, S.L.Buza, J.[Polymorphisms of the chicken Mx gene promoter and association with chicken embryos’ susceptibility to virulent Newcastle disease virus challenge]Polymorphisms of the chicken Mx gene promoter and association with chicken embryos’ susceptibility to virulent Newcastle disease virus challenge

There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by the protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, ...


Norling, M.Bishop, Richard P.Pelle, RogerWeihong QiHenson, S.Drábek, E.F.Tretina, K.Odongo, D.Mwaura, S.Njoroge, T.Bongcam-Rudloff, E.Daubenberger, C.A.Silva, J.C.[The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence]The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence

Background Theileria parva is an intracellular parasite that causes a lymphoproliferative disease in cattle. It does so by inducing cancer-like phenotypes in the host cells it infects, although the molecular and regulatory mechanisms involved remain poorly understood. RNAseq data, and the resulti...


Tretina, K.Pelle, RogerSilva, J.C.[Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva]Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva
Hassan, S.Skilton, R.A.Pelle, RogerOdongo, D.Bishop, Richard P.Ahmed, J.Seitzer, U.Bakheit, M.Hassan, S.M.El Hussein, A.M.[Assessment of the prevalence of Theileria lestoquardi in sheep from the Sudan using serological and molecular methods]Assessment of the prevalence of Theileria lestoquardi in sheep from the Sudan using serological and molecular methods

East Coast fever is a lymphoproliferative disease caused by the tick-borne protozoan parasite Theileria parva. The sporozoite stage of this parasite, harboured and released from the salivary glands of the tick Rhipicephalus appendiculatus during feeding, invades and establishes infection in bovin...


Nyagwange, JamesTijhaar, EdwinTernette, NicolaMobegi, FredrickTretina, KyleSilva, Joana C.Pelle, RogerNene, Vishvanath[Characterization of the Theileria parva sporozoite proteome]Characterization of the Theileria parva sporozoite proteome

Nyagwange, JamesTernette, NicolaTijhaar, EdwinPelle, RogerNene, Vishvanath[Proteomics of Theileria parva sporozoites]Proteomics of Theileria parva sporozoites

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