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East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with...


Nyagwange, JamesNene, VishvanathMwalimu, Stephen M.Henson, Sonal P.Steinaa, LucillaNzau, Benjamin M.Tijhaar, EdwinPelle, Roger[Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro]Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro

Theileriosis, caused by parasitic protozoa of the genus Theileria parasites, are among the major tick-borne diseases of ruminant livestock. The largest economic losses are attributed in particular to those caused by the leukoproliferative species of Theileria: T. parva, T. annulata and T. lestoqu...


Ali, A.M.Salih, Diaeldin A.Njahira, Moses N.Hassan, S.K.Hussein, A.M.E.Liu, Z.Yin, H.Pelle, RogerSkilton, Robert A.[Genotyping of Theileria lestoquardi from sheep and goats in Sudan to support control of Malignant Ovine Theileriosis]Genotyping of Theileria lestoquardi from sheep and goats in Sudan to support control of Malignant Ovine Theileriosis

An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions ...


Hemmink, J.D.Weir, W.MacHugh, Niall D.Graham, S.P.Patel, EktaPaxton, E.Shiels, B.Toye, Philip G.Morrison, W. IvanPelle, Roger[Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva]Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva

East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite. Parasite antigens that are targets of protective cytotoxic T lymphocyte (CTL) responses are required to formulate a sub-unit vaccine against ...


Akoolo, L.Pelle, RogerSaya, R.Awino, EliasNyanjui, J.Taracha, E.L.N.Kanyari, P.Mwangi, D.M.Graham, S.P.[Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle]Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
Mwangi, D.M.Graham, S.P.Pelle, RogerHonda, Y.Tonukari, N.J.Yamage, I.M.Glew, E.J.Villiers, Etienne P. deShah, TushaarBishop, Richard P.Abuya, E.Awino, EliasGachanja, J.Luyai, A.E.Mbwika, F.Muthiani, A.M.Ndegwa, D.M.Njahira, Moses N.Nyanjui, J.K.Onono, F.O.Osaso, J.Saya, R.M.Wildmann, C.Fraser, C.M.Maudlin, I.Gardner, M.J.Morzaria, S.P.Loosmore, S.Gilbert, S.C.Audonnet, J.C.Bruggen, P. van derNene, VishvanathTaracha, E.L.N.[Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?]Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?

The development of a sterilizing and cost-effective vaccine against malaria remains a major problem despite recent advances. In this study, it is demonstrated that two antigens of P. falciparum UB05, UB09 and their chimera UB05-09 can serve as protective immunity markers by eliciting higher T-cel...


Dinga, J.N.Njimoh, D.L.Kiawa, B.Djikeng, AppolinaireNyasa, R.B.Nkuo-Akenji, T.Pelle, RogerTitanji, V.P.K.[Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria]Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria

Nyagwange, JamesTernette, NicolaTijhaar, EdwinPelle, RogerNene, Vishvanath[Proteomics of Theileria parva sporozoites]Proteomics of Theileria parva sporozoites
Sitt, T.Pelle, RogerChepkwony, M.C.Morrison, W. IvanToye, Philip G.[Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines]Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines

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