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Silatsa, Barberine A.Simo, GustaveGithaka, Naftaly W.Mwaura, StephenKamga, Rolin M.Oumarou, FariikouTiambo, Christian K.Bishop, Richard P.Djikeng, AppolinaireKuiate, Jules-RogerNjiokou, FlobertPelle, Roger[A comprehensive survey of the prevalence and spatial distribution of ticks infesting cattle in different agro-ecological zones of Cameroon]A comprehensive survey of the prevalence and spatial distribution of ticks infesting cattle in different agro-ecological zones of Cameroon
Amzati, Gaston S.Pelle, RogerMuhigwa, J.B.Kanduma, E.G.Djikeng, AppolinaireMadder, M.Kirschvink, N.Marcotty, T.[Mitochondrial phylogeography and population structure of the cattle tick Rhipicephalus appendiculatus in the African Great Lakes region]Mitochondrial phylogeography and population structure of the cattle tick Rhipicephalus appendiculatus in the African Great Lakes region

East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with...


Nyagwange, JamesNene, VishvanathMwalimu, Stephen M.Henson, Sonal P.Steinaa, LucillaNzau, Benjamin M.Tijhaar, EdwinPelle, Roger[Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro]Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro

Theileriosis, caused by parasitic protozoa of the genus Theileria parasites, are among the major tick-borne diseases of ruminant livestock. The largest economic losses are attributed in particular to those caused by the leukoproliferative species of Theileria: T. parva, T. annulata and T. lestoqu...


Ali, A.M.Salih, Diaeldin A.Njahira, Moses N.Hassan, S.K.Hussein, A.M.E.Liu, Z.Yin, H.Pelle, RogerSkilton, Robert A.[Genotyping of Theileria lestoquardi from sheep and goats in Sudan to support control of Malignant Ovine Theileriosis]Genotyping of Theileria lestoquardi from sheep and goats in Sudan to support control of Malignant Ovine Theileriosis

Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...


Pelle, RogerGraham, S.P.Njahira, Moses N.Osaso, J.Saya, R.M.Odongo, David O.Toye, Philip G.Spooner, P.R.Musoke, A.J.Mwangi, D.M.Taracha, E.L.N.Morrison, W. IvanWeir, W.Silva, J.Bishop, Richard P.[Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity]Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity

An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions ...


Hemmink, J.D.Weir, W.MacHugh, Niall D.Graham, S.P.Patel, EktaPaxton, E.Shiels, B.Toye, Philip G.Morrison, W. IvanPelle, Roger[Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva]Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva

Tremendous progress has been made over the last ten years on East Coast fever (ECF) research. Publication of a reference genome sequence of Theileria parva, the causative agent of ECF, has led to a more thorough characterization of the genotypic and antigenic diversity of the pathogen. It also fa...


Nene, VishvanathKiara, Henry K.Lacasta, AnnaPelle, RogerSvitek, NicholasSteinaa, Lucilla[The biology of Theileria parva and control of East Coast fever—Current status and future trends]The biology of Theileria parva and control of East Coast fever—Current status and future trends

Massively parallel signature sequencing (MPSS) was used to analyze the transcriptome of the intracellular protozoan Theileria parva. In total 1 095 000, 20 bp sequences representing 4371 different signatures were generated from T.parva schizonts. Reproducible signatures were identified within 73%...


Bishop, Richard P.Shah, TushaarPelle, RogerHoyle, D.Pearson, T.Haines, L.Brass, A.Hulme, H.Graham, S.P.Taracha, E.L.N.Lu, C.Hass, B.Wortman, J.White, O.Gardner, M.J.Nene, VishvanathVilliers, Etienne P. de[Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage]Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage

Transcriptome analysis can provide useful data for refining genome sequence annotation. Application of massively parallel signature sequencing (MPSS) revealed reproducible transcription, in multiple MPSS cycles, from 73% of computationally predicted genes in the Theileria parva schizont lifecycle...


Shah, TushaarVilliers, Etienne P. deNene, VishvanathHass, B.Taracha, E.A.Gardner, J.M.Sansom, C.Pelle, RogerBishop, Richard P.[Using the transcriptome to annotate the genome revisited: application of massively parallel signature sequencing (MPSS)]Using the transcriptome to annotate the genome revisited: application of massively parallel signature sequencing (MPSS)

East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-i...


Graham, S.P.Pelle, RogerHonda, Y.Mwangi, D.M.Tonukari, N.J.Yamage, M.Glew, E.J.Villiers, Etienne P. de[Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes]Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes

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