An isolate of T. vivax was collected from a naturally infected Zebu in French Guyana. The isolate was subsequently shown to produce pathogenic infections in both Taurine and Zebu cattle. However, its sensitivity of the population to diminazene aceturate and isometamidium chloride was determined s...
Desquesnes, M.
,
Rocque, S. de la
,
Peregrine, A.S.
,
[French Guyanan stock of Trypanosoma vivax resistant to diminazene aceturate but sensitive to isometamidium chloride]
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French Guyanan stock of Trypanosoma vivax resistant to diminazene aceturate but sensitive to isometamidium chloride
Experiments were carried out in goats to determine the frequency with which diminazene-resistant trypanosomes occur in parasite populations before and after the intramuscular treatment of the goats with diminazene aceturate. Trypanosoma congolense IL3274, a diminazene-resistant clone, was used to...
Mamman, M.
,
Williams, D.J.L.
,
Murphy, N.B.
,
Peregrine, A.S.
,
[Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense]
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Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense
Six Boran cattle were infected with the drug-resistant Trypanosoma congolense IL 3338. At the first peak of parasitemia different groups of 200 teneral Glossina morsitans centralis were fed once on each animal, just prior to treatment with diminazene aceturate at a dose of 3.5 mg kg-1 body weight...
Diack, A.
,
Moloo, S.K.
,
Peregrine, A.S.
,
[Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis]
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Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis
Field studies were conducted to assess the occurrence of resistance to isometamidium chloride and diminazene aceturate in trypanosomes infecting cattle in Kenedougou Province of Burkina Faso. Forty-five of the 166 villages in Kenedougou were randomly sampled and visited to assess livestock numb...
McDermott, John J.
,
Woitag, T.
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Sidibe, I.
,
Bauer, B.
,
Diarra, B.
,
Ouédraogo, D.
,
Kamuanga, M.
,
Peregrine, A.S.
,
Eisler, M.C.
,
Zessin, K.H.
,
[Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso]
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Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso
Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...
Eisler, M.C.
,
Brandt, J.
,
Bauer, B.
,
Clausen, P.H.
,
Delespaux, V.
,
Holmes, P.H.
,
Ilemobade, A.
,
Machila, N.
,
Mbwambo, H.
,
McDermott, John J.
,
Mehlitz, D.
,
Murilla, G.
,
Ndung'u, J.M.
,
Peregrine, A.S.
,
Sidibe, I.
,
Sinyangwe, L.
,
Geerts, S.
,
[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]
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Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle
Isometamidium chloride is the most important chemoprophylactic agent used in the control of African bovine trypanosomiasis, although breakdowns in prophylaxis have been observed in the field. It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the...
Eisler, M.C.
,
Maloo, S.H.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Thorpe, W.R.
,
[Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya]
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Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya
A study was undertaken to compare the absorption and distribution of the antitrypanosomal drug diminazene aceturate in plasma, cerebrospinal fluid (CSF) and lymph of goats. The study comprised three groups of three goats each. Animals in each group were treated with a single intramuscular dose of...
Mamman, M.
,
McKeever, Declan J.
,
Peregrine, A.S.
,
[Comparative pharmacokinetics of diminazene in plasma, cerebrospinal fluid and lymph of goats]
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Comparative pharmacokinetics of diminazene in plasma, cerebrospinal fluid and lymph of goats
Isometamidium chloride (Samorin, Trypanidium is a phenanthridine-aromatic amidine that is commonly used in cattle as a prophylactic agent against trypanosomiasis. Although the compound has been used for over 30 years, very little is known about its mode of action. Various workers have demonstrate...
Peregrine, A.S.
,
Eisler, M.C.
,
Flynn, J.N.
,
Katende, J.
,
Gault, E.A.
,
Kinabo, L.D.B.
,
Homes, P.H.
,
[Generation of monoclonal antibodies to the anti-trypanosomal drug Samorin]
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Generation of monoclonal antibodies to the anti-trypanosomal drug Samorin
Besides the in vitro test, two tests are very commonly used for the detection of trypanocidal drug resistance: the tests in mice and in ruminants. Since it has been shown that several parameters such as the number of trypanosomes inoculated and the time of treatment might influence the outcome of...
Geerts, S.
,
Ndung'u, J.M.
,
Murilla, G.
,
Mbwambo, H.
,
Sirryangwe, L.
,
Machila, N.
,
Delespaux, V.
,
Brandt, J.
,
Peregrine, A.S.
,
McDermott, John J.
,
Holmes, P.H.
,
Eisler, M.C.
,
[In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants]
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In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants
To determine the duration after treatment of cattle with diminazene aceturate that the drug influences the tsetse infectivity and transmissibility of a drug-resistant Trypanosoma congolense, six Boran cattle were infected with T. congolense IL 3338 via the bites of Glossina morsitans centralis. A...
Diack, A.
,
Moloo, S.K.
,
Peregrine, A.S.
,
[Effect of diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense in Glossina morsitans centralis]
,
Effect of diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense in Glossina morsitans centralis