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Hirumi, H.Hirumi, K.Peregrine, A.S.[Axenic culture of Trypanosoma congolense: Application to the detection of sensitivity levels of bloodstream Trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate]Axenic culture of Trypanosoma congolense: Application to the detection of sensitivity levels of bloodstream Trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate

Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kenedougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubatio...


Knoppe, T.N.Bauer, B.McDermott, John J.Peregrine, A.S.Mehlitz, D.Clausen, P.H.[Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test]Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test

A study was carried out to determine whether a drug-resistant trypanosome population could influence the survival of a drug-sensitive population in mixed infections in goats. To identify both populations during the course of a mixed infection, a system for distinguishing them was developed; using...


Burudi, E.M.E.Peregrine, A.S.Majiwa, P.A.O.Mbiuki, S.M.Murphy, N.B.[Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats]Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats
Mamman, M.Moloo, S.K.Peregrine, A.S.[Relapse of Trypanosoma congolense infection in goats after diminazene aceturate is not a result of invasion of the central nervous system]Relapse of Trypanosoma congolense infection in goats after diminazene aceturate is not a result of invasion of the central nervous system

Field studies were conducted to assess the occurrence of resistance to isometamidium chloride and diminazene aceturate in trypanosomes infecting cattle in Kenedougou Province of Burkina Faso. Forty-five of the 166 villages in Kenedougou were randomly sampled and visited to assess livestock numb...


McDermott, John J.Woitag, T.Sidibe, I.Bauer, B.Diarra, B.Ouédraogo, D.Kamuanga, M.Peregrine, A.S.Eisler, M.C.Zessin, K.H.[Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso]Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso
Gray, M.A.Kimarua, R.W.Peregrine, A.S.[Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya]Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya

A method is described for calculating new infection incidence from monthly field data collected between April 1994 and February 1998 from an average of 770 Ethiopian Highland Zebu cattle maintained under traditional management in the Ghibe valley, southwest Ethiopia and exposed to a high challeng...


Rowlands, G.J.Leak, S.G.A.Peregrine, A.S.Nagda, S.M.Mulatu, W.D'Ieteren, G.D.M.[The incidence of new and the prevalence and persistence of recurrent trypanosome infections in cattle in southewest Ethiopia exposed to a high challenge with drug-resistant parasites]The incidence of new and the prevalence and persistence of recurrent trypanosome infections in cattle in southewest Ethiopia exposed to a high challenge with drug-resistant parasites

Ten trypanosome isolates were collected at random from cattle at Ghibe, Ethiopia, in February 1993 and all shown to be savannah-type Trypanosoma congolense. When inoculated into naive Boran (Bos indicus) calves, all 10 isolates were resistant to diminazene aceturate (Berenil), isometamidium chlor...


Mulugeta, W.Wilkes, J.Mulatu, W.Majiwa, P.A.O.Masake, R.Peregrine, A.S.[Long-term occurrence of Trypanosoma congolense resistant to diminazene, isometamidium and homidium in cattle at Ghibe, Ethiopia]Long-term occurrence of Trypanosoma congolense resistant to diminazene, isometamidium and homidium in cattle at Ghibe, Ethiopia

Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...


Eisler, M.C.Brandt, J.Bauer, B.Clausen, P.H.Delespaux, V.Holmes, P.H.Ilemobade, A.Machila, N.Mbwambo, H.McDermott, John J.Mehlitz, D.Murilla, G.Ndung'u, J.M.Peregrine, A.S.Sidibe, I.Sinyangwe, L.Geerts, S.[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle

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