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Waitumbi, J.N.Murphy, N.B.Peregrine, A.S.[Genotype and drug-resistance phenotype of Trypanosoma evansi originating from camels in Northern Kenya]Genotype and drug-resistance phenotype of Trypanosoma evansi originating from camels in Northern Kenya
Peregrine, A.S.Ogunyemi, O.Whitelaw, D.D.Holmes, P.H.Moloo, S.K.Hirumi, H.Urquhart, G.M.Murray, M.[Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense]Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense

Bloodstream forms of four populations of the livestock pathogen Trypanosoma congolense, isolated from different natural infections, have been shown to exhibit a wide range of sensitivities to the trypanocide isometamidium chloride (Samorin). In mice the 50 percent curative doses (CD 50) for Samor...


Wilkes, J.M.Mulugeta, W.Wells, C.Peregrine, A.S.[Modulation of mitochondrial electrical potential: A candidate mechanism for drug resistance in African trypanosomes]Modulation of mitochondrial electrical potential: A candidate mechanism for drug resistance in African trypanosomes

Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectivel...


Peregrine, A.S.Gray, M.A.Moloo, S.K.[Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense]Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense
Murphy, N.B.Muthiani, M.Peregrine, A.S.[Use of an in vivo system to determine the G418 resistance phenotype of bloodstream-form Trypanosoma brucei brucei transfectants]Use of an in vivo system to determine the G418 resistance phenotype of bloodstream-form Trypanosoma brucei brucei transfectants

Interaction of the trypanocide isometamidium chloride with components of Trypanosoma congolense results in characteristic shifts in the intrinsic fluorescence of the drug. The specificity of this interaction was investigated by analysing the effects of various physiochemical manipulations on its ...


Wilkes, J.M.Peregrine, A.S.Zilberstein, D.[The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence]The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence
Ndoutamia, G.Moloo, S.K.Murphy, N.B.Peregrine, A.S.[Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense]Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense
Sutherland, I.A.Codjia, V.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Therapeutic activity of isometamidium chloride in Boran cattle against a clone of Trypanosoma congolense with a low level of drug resistance]Therapeutic activity of isometamidium chloride in Boran cattle against a clone of Trypanosoma congolense with a low level of drug resistance
Sutherland, I.A.Peregrine, A.S.Lonsdale-Eccles, J.D.Holmes, P.H.[Reduced accumulation of isometamidum by drug resistant Trypanosoma congolense]Reduced accumulation of isometamidum by drug resistant Trypanosoma congolense

Two groups of five Boran (Bos indicus) cattle were infected with one of two populations of Trypanosoma congolense; one drug-sensitive (IL1180), and one drug-resistant (IL3330). The animals were then treated intramuscularly with homidium bromide at a dose rate of 1.0 mg kg - bodyweight 7 days afte...


Murilla, G.A.Peregrine, A.S.Ndung'u, J.M.Holmes, P.H.Eisler, M.C.[The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle]The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle

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