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Two enzyme-linked immunosorbent assays (ELISA) for the determination of homidium in serum of treated cattle have been developed and evaluated. One is a direct competition (Assay 1) and the other an indirect competition assay (Assay 2). Both assays are highly sensitive with a limit of detection of...


Murilla, G.Eisler, M.C.Peregrine, A.S.Ndung'u, J.M.Holmes, P.H.[Development and evaluation of an enzyme-linked immunosorbent assay (ELISA) for the determination of the trypanocidal drug homidium in serum of treated cattle]Development and evaluation of an enzyme-linked immunosorbent assay (ELISA) for the determination of the trypanocidal drug homidium in serum of treated cattle

Pharmacokinetic studies on the trypanocidal drug homidium bromide using a competitive enzyme immunoassay (detection limit 0.1 ng/mL) are reported for non-infected Friesian and Boran steers following treatment with homidium bromide at a dose of 1.0 mg/kg b.w. Following intravenous (i.v.) treatment...


Murilla, G.Holmes, P.H.Peregrine, A.S.Eisler, M.C.Ndung'u, J.M.[Some pharmacokinetic parameters of the trypanocidal drug homidium bromide in Friesian and Boran steers using an enzyme-linked immunosorbent assay (ELISA)]Some pharmacokinetic parameters of the trypanocidal drug homidium bromide in Friesian and Boran steers using an enzyme-linked immunosorbent assay (ELISA)

To determine the duration after treatment of cattle with diminazene aceturate that the drug influences the tsetse infectivity and transmissibility of a drug-resistant Trypanosoma congolense, six Boran cattle were infected with T. congolense IL 3338 via the bites of Glossina morsitans centralis. A...


Diack, A.Moloo, S.K.Peregrine, A.S.[Effect of diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense in Glossina morsitans centralis]Effect of diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense in Glossina morsitans centralis

Describes the epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia, the tsetse populations and their relationships to the prevalence of trypanosome infections in cattle. The tsetse challenge to cattle at two sites in the area was estimated as the product of tsetse relati...


Leak, S.G.A.Mulatu, W.Authié, E.D'Ieteren, G.D.M.Peregrine, A.S.Rowlands, G.J.Trail, J.C.M.[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 1. Tsetse challenge and its relationship to trypanosome prevalence in cattle]Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 1. Tsetse challenge and its relationship to trypanosome prevalence in cattle

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