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Zilberstein, D.Wilkes, J.M.Hirumi, H.Peregrine, A.S.[Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense]Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense
Peregrine, A.S.Hirumi, H.Zilberstein, D.[Fluorescence analysis of the interaction of isometamidium (Samorin) with Trypanosoma congolense]Fluorescence analysis of the interaction of isometamidium (Samorin) with Trypanosoma congolense

Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognize...


Peregrine, A.S.Eisler, M.C.Katende, J.Flynn, J.N.Gault, E.A.Kinabo, L.D.B.Holmes, P.H.[Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium]Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium
Hirumi, H.Hirumi, K.Peregrine, A.S.[Axenic culture of Trypanosoma congolense: Application to the detection of sensitivity levels of bloodstream Trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate]Axenic culture of Trypanosoma congolense: Application to the detection of sensitivity levels of bloodstream Trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate
Gray, M.A.Kimarua, R.W.Peregrine, A.S.[Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya]Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya
Waitumbi, J.N.Murphy, N.B.Peregrine, A.S.[Genotype and drug-resistance phenotype of Trypanosoma evansi originating from camels in Northern Kenya]Genotype and drug-resistance phenotype of Trypanosoma evansi originating from camels in Northern Kenya
Peregrine, A.S.Ogunyemi, O.Whitelaw, D.D.Holmes, P.H.Moloo, S.K.Hirumi, H.Urquhart, G.M.Murray, M.[Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense]Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense

Interaction of the trypanocide isometamidium chloride with components of Trypanosoma congolense results in characteristic shifts in the intrinsic fluorescence of the drug. The specificity of this interaction was investigated by analysing the effects of various physiochemical manipulations on its ...


Wilkes, J.M.Peregrine, A.S.Zilberstein, D.[The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence]The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence
Ndoutamia, G.Moloo, S.K.Murphy, N.B.Peregrine, A.S.[Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense]Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense

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