Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system, maintenance of cell function and differentiation, epithelial surfa...
Bono, M.R.
,
Tejon, G.
,
Flores-Santibañez, F
,
Fernandez, D.
,
Rosemblatt, M.
,
Sauma, D.
,
[Retinoic acid as a modulator of T cell immunity]
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Retinoic acid as a modulator of T cell immunity
Adoptive transfer of CD4+CD25+FOXP3+ regulatory T cells (Treg cells) has been successfully utilized to treat graft versus host disease and represents a promising strategy for the treatment of autoimmune diseases and transplant rejection. The aim of this study was to evaluate the effects of all-tr...
Candia, E.
,
Reyes, P.
,
Covian, C.
,
Rodriguez, F.
,
Wainstein, N.
,
Morales, J.
,
Mosso, C.
,
Rosemblatt, M.
,
Fierro, J.A.
,
[Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells]
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Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
Memory CD8+ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8+ T cell effector subsets to persist and become memory cells has not been fully characterized. Type...
Flores-Santibáñez, F.
,
Cuadra, B.
,
Fernández, D.
,
Rosemblatt, M.V.
,
Núñez, S.
,
Cruz, P.
,
Gálvez-Cancino, F.
,
César Cárdenas, J.
,
Lladser, A.
,
Rosemblatt, M.
,
Bono, M.R.
,
Sauma, D.
,
[In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo]
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In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo