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Taracha, E.L.N.Irvin, A.D.Morzaria, S.P.Moloo, S.K.Katende, J.M.Kiarie, J.N.[Effect of chronic trypanosomiasis on immunization against East Coast fever]Effect of chronic trypanosomiasis on immunization against East Coast fever

Peripheral blood mononuclear cells (PBMC) from immune cattle proliferate in the presence of autologous Cowdria ruminantium-infected endothelial cells and monocytes. Endothelial cells required treatment with T-cell growth factors to induce class II major histocompatibility complex expression prior...


Mwangi, D.M.Mahan, S.M.Nyanjui, J.K.Taracha, E.L.N.McKeever, Declan J.[Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes]Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes

We evaluated sexual recombination in the apicomplexan parasite Theileria parva using genome-wide marker analysis of haploid sporozoite populations obtained from infected Rhipicephalus appendiculatus ticks. Analysis of 231 parasite clones derived by in vitro infection of bovine lymphocytes reveale...


Katzer, F.Ngugi, D.Oura, C.Bishop, Richard P.Taracha, E.L.N.Walker, A.R.McKeever, Declan J.[Extensive genotypic diversity in a recombining population of the apicomplexan parasite Theileria parva]Extensive genotypic diversity in a recombining population of the apicomplexan parasite Theileria parva
Taracha, E.L.N.Goddeeris, M.Scott, J.R.Morrison, W. Ivan[Standardization of a technique for analysing the frequency of parasite-specific cytotoxic T lymphocyte precursors in cattle immunized with Theileria parva]Standardization of a technique for analysing the frequency of parasite-specific cytotoxic T lymphocyte precursors in cattle immunized with Theileria parva
Howard, C.J.Sopp, P.Parsons, K.R.McKeever, Declan J.Taracha, E.L.N.Jones, B.V.MacHugh, Niall D.Morrison, W. Ivan[Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45]Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45

The relationship of strain specificity of class I major histocompatibility complex-restricted parasite-specific cytotoxic T lymphocytes (CTL) responses and cross-protection was investigated in an effort to verify the role of CTL in protection. The parasite strain specificity of the CTL responses ...


Taracha, E.L.N.Goddeeris, B.M.Morzaria, S.P.Morrison, W. Ivan[Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva]Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva

Heterologous priming-boosting vaccination regimens involving priming with plasmid DNA antigen constructs and inoculating (boosting) with the same recombinant antigen expressed in replication-attenuated poxviruses have recently been demonstrated to induce immunity, based on CD4(+)- and CD8(+)-T-c...


Taracha, E.L.N.Bishop, Richard P.Musoke, A.J.Hill, A.V.S.Gilbert, S.C.[Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses]Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses

Theileria parva causes an acute lympho-proliferative disease in cattle, which can result in death of susceptible animals within 2-3 weeks of infection. Analyses of the cellular response in the lymph node draining the site of infection demonstrated an early T cell response, with the appearance of ...


Houston, E.F.Taracha, E.L.N.Brackenbury, L.MacHugh, Niall D.McKeever, Declan J.Charleston, B.Morrison, W. Ivan[Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function]Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function

The importance of T-cell-mediate immune responses in the control of intracellular protozoan parasites is now well established 1-3. The killing of parasitized cells by T cells and cytokine-mediated effects on growth and viability of the intracellular parasites have both been implicated as effector...


Morrison, W. IvanTaracha, E.L.N.McKeever, Declan J.[Contribution of T-cell responses to immunity and pathogenesis in infection with Theileria parva]Contribution of T-cell responses to immunity and pathogenesis in infection with Theileria parva

Studies of the immune responses of cattle to Theileria parva have provided evidence that immunity to the parasite can operate at two levels, namely the sporozoite and the schizont-infected lymphoblast. Antibodies that neutralize the infectivity of sporozoites have been detected in the serum of hy...


Morrison, W. IvanTaracha, E.L.N.McKeever, Declan J.[Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite]Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite

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