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There is an alarming rate of human African trypanosomiasis recrudescence in many parts of sub-Saharan Africa. Yet, the disease has no successful chemotherapy. Trypanosoma lacks the enzymatic machinery for the de novo synthesis of purine nucleotides, and is critically dependent on salvage mechanis...


Tomoaki BesshoShoko MoriiToshihide KusumotoTakahiro ShinoharaMasanori NodaSusumu UchiyamaSatoshi ShutoShigenori NishimuraShigenori NishimuraDuszenko, M.Martin, S.K.Takashi InuiKubata, K.B.[Characterization of the novel Trypanosoma brucei inosine 5′-monophosphate dehydrogenase]Characterization of the novel Trypanosoma brucei inosine 5′-monophosphate dehydrogenase

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