East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-i...
Graham, S.P.
,
Pelle, Roger
,
Honda, Y.
,
Mwangi, D.M.
,
Tonukari, N.J.
,
Yamage, M.
,
Glew, E.J.
,
Villiers, Etienne P. de
,
[Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes]
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Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
Reassociation kinetics and flow cytometry data indicate that ixodid tick genomes are large, relative to most arthropods, containing ≥ 109 base pairs. The molecular basis for this is unknown. We have identified a novel small interspersed element with features of a tRNA-derived SINE, designated Ruk...
Sunter, J.D.
,
Patel, S.P.
,
Skilton, Robert A.
,
Knowles, Donald P.
,
Scoles, Glen A.
,
Nene, Vishvanath
,
Villiers, Etienne P. de
,
Bishop, Richard P.
,
[A novel SINE family occurs frequently in both genomic DNA and transcribed sequences in ixodid ticks of the arthropod sub-phylum Chelicerata]
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A novel SINE family occurs frequently in both genomic DNA and transcribed sequences in ixodid ticks of the arthropod sub-phylum Chelicerata
Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development ...
Graham, S.P.
,
Honda, Y.
,
Pelle, Roger
,
Mwangi, D.M.
,
Glew, E.J.
,
Villiers, Etienne P. de
,
Shah, Tushaar
,
Bishop, Richard P.
,
Bruggen, P. van der
,
Nene, Vishvanath
,
Taracha, E.L.N.
,
[A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology]
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A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology
Rab genes encode a subgroup of small GTP-binding proteins within the ras super-family that regulate targeting and fusion of transport vesicles within the secretory and endocytic pathways. These genes are of particular interest in the protozoan phylum Apicomplexa, since a family of Rab GTPases has...
Langsley, G.
,
Noort, V. van
,
Carret, C.
,
Meissner, M.
,
Villiers, Etienne P. de
,
Bishop, Richard P.
,
Pain, A.
,
[Comparative genomics of the Rab protein family in Apicomplexan parasites]
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Comparative genomics of the Rab protein family in Apicomplexan parasites
Bishop, Richard P.
,
Odongo, David O.
,
Mann, D.J.
,
Pearson, T.W.
,
Sugimoto, C.
,
Haines, L.R.
,
Glass, E.
,
Jensen, K.
,
Seitzer, U.
,
Ahmed, J.S.
,
Graham, S.P.
,
Villiers, Etienne P. de
,
[Theileria]
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Theileria
Haemonchosis is considered to be the most economically important gastrointestinal disease of small ruminants in the tropics and subtropics. However, chemical anthelmintics, which were the mainstay of control, have been compromised by a high prevalence of resistance worldwide. Copper oxide wire pa...