The use of tick vaccines in mammalian hosts has been shown to be the most promising alternative tick control method to current use of acaricides, which suffers from a number of limitations. However, the success of this method is dependent on the identification cloning, and in vitro expression of ...
Mulenga, A.
,
Sugimoto, C.
,
Sako, C.
,
Ohashi, K.
,
Musoke, A.J.
,
Shubash, M.
,
Onuma, M.
,
[Molecular characterization of Haemaphysalis longicornis tick salivary gland-associated 29-kilodalton protein and its effect as a vaccine against tick infestation in rabbits]
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Molecular characterization of Haemaphysalis longicornis tick salivary gland-associated 29-kilodalton protein and its effect as a vaccine against tick infestation in rabbits
A stage-specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in cattle. By Pepscan analysis with a series of overlapping synthetic p67 peptides, the antigen was shown to contain five distinct lin...
Nene, Vishvanath
,
Gobright, E.I.
,
Bishop, Richard P.
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Morzaria, S.P.
,
Musoke, A.J.
,
[Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralising epitopes: Implications for a vaccine]
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Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralising epitopes: Implications for a vaccine
In this paper, available data on the distribution, economic importance and efforts made so far towards the control of Newcastle Disease (ND) in Ethiopia were presented. ND is the single major health constraint, which causes heavy mortality and morbidity to village chicken and affects productivity...
Dessie, Tadelle
,
Jobre, Y.
,
[A review of the importance and control of Newcastle disease in Ethiopia]
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A review of the importance and control of Newcastle disease in Ethiopia
Immunity to Theileria parva infection in cattle is often parasite stock specific. The antigenic diversity which is expressed at the schizont stage of the parasite together with a wild reservoir of the organism in buffalo has complicated the development of effective disease control by immunization...
Nene, Vishvanath
,
Musoke, A.J.
,
Gobright, E.I.
,
Morzaria, S.P.
,
[Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles]
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Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles
Studies of the immune responses of cattle to Theileria parva have provided evidence that immunity to the parasite can operate at two levels, namely the sporozoite and the schizont-infected lymphoblast. Antibodies that neutralize the infectivity of sporozoites have been detected in the serum of hy...
Morrison, W. Ivan
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Taracha, E.L.N.
,
McKeever, Declan J.
,
[Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite]
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Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite
The role that partnership has played in enabling its global impacts is highlighted in this Report. ILRI collaborates with a wealth of institutions at national, regional and international levels. An example of partnership at each level is highlighted. The examples Reported are, 1) Poverty mapping ...
Outlines the types of reforms introduced in animal health services over the past decade, summarises past experiences, provides a preliminary assessment of their impact, and indicates what lessons need to be taken into account in future policy adjustments and project investments. The discussion co...
Haan, C. de
,
Solomon Bekure
,
[Animal health services in sub-Saharan Africa: Initial experience with new approaches]
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Animal health services in sub-Saharan Africa: Initial experience with new approaches
Rift Valley Fever virus (RVFV) causes recurrent outbreaks of acute life-threatening human and livestock illness in Africa and the Arabian Peninsula. No licensed vaccines are currently available for humans and those widely used in livestock have major safety concerns. A ‘One Health’ vaccine develo...
Warimwe, G.M.
,
Gesharisha, J.
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Carr, B.V.
,
Otieno, S.
,
Otingah, K.
,
Wright, D.
,
Charleston, B.
,
Okoth, Edward A.
,
Elena, L.G.
,
Lorenzo, G.
,
Ayman, E.B.
,
Alharbi, N.K.
,
Al-Dubaib, M.A.
,
Brun, A.
,
Gilbert, S.C.
,
Nene, Vishvanath
,
Hill, A.V.S.
,
[Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever]
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Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever
To identify the genes encoding novel immunodominant antigens of Theileria parvo a ?gt11 library of piroplasm genomic DNA was immunoscreened with bovine recovery serum and a gene encoding a 150 kDa antigen (p150) was identified. The predicted polypeptide contains an N-terminal secretory signal seq...
Skilton, Robert A.
,
Bishop, Richard P.
,
Wells, C.W.
,
Spooner, P.R.
,
Gobright, E.I.
,
Nkonge, C.
,
Musoke, A.J.
,
Macklin, M.D.
,
Iams, K.P.
,
[Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)]
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Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)